TY - JOUR
T1 - Laparoscopic Versus Open Pancreatoduodenectomy in Patients with Periampullary Tumors
T2 - A Systematic Review and Meta-analysis
AU - Sattari, Shahab Aldin
AU - Sattari, Ali Reza
AU - Makary, Martin A.
AU - Hu, Chen
AU - He, Jin
N1 - Publisher Copyright:
© Copyright 2023 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2023/5/1
Y1 - 2023/5/1
N2 - Objective: To conduct a systematic review and meta-analysis of randomized controlled trials compared laparoscopic pancreatoduodenectomy (LPD) versus open pancreatoduodenectomy (OPD) in patients with periampullary tumors. Background: LPD has gained attention; however, its safety and efficacy versus OPD remain debatable. Methods: We searched PubMed and Embase. Primary outcomes were the length of hospital stay (LOS) (day), Clavien-Dindo grade ≥III complications, and 90-day mortality. Secondary outcomes were blood loss (milliliter), blood transfusion, duration of operation (minute), readmission, reoperation, comprehensive complication index score, bile leak, gastrojejunostomy or duodenojejunostomy leak, postoperative pancreatic fistula, postpancreatectomy hemorrhage, delayed gastric emptying, surgical site infection, intra-abdominal infection, number of harvested lymph nodes, and R0 resection. Pooled odds ratio (OR) or mean difference (MD) of data was calculated using the random-effect model. The grading of recommendations, assessment, development and evaluation approach was used for grading the level of evidence. Results: Four randomized controlled trials yielding 818 patients were included, of which 411 and 407 patients underwent LPD and OPD, respectively. The meta-analysis concluded that 2 approaches were similar, except in the LPD group, the LOS tended to be shorter [MD=-2.54 (-5.17, 0.09), P=0.06], LOS in ICU was shorter [MD=-1 (-1.8, -0.2), P=0.01], duration of operation was longer [MD=75.16 (23.29, 127.03), P=0.005], blood loss was lower [MD=-115.40 (-152.13, -78.68), P<0.00001], blood transfusion was lower [OR=0.66 (0.47, 0.92), P=0.01], and surgical site infection was lower [OR=0.35 (0.12, 0.96), P=0.04]. The overall certainty of the evidence was moderate. Conclusions: Within the hands of highly skilled surgeons in high-volume centers, LPD is feasible and as safe and efficient as OPD.
AB - Objective: To conduct a systematic review and meta-analysis of randomized controlled trials compared laparoscopic pancreatoduodenectomy (LPD) versus open pancreatoduodenectomy (OPD) in patients with periampullary tumors. Background: LPD has gained attention; however, its safety and efficacy versus OPD remain debatable. Methods: We searched PubMed and Embase. Primary outcomes were the length of hospital stay (LOS) (day), Clavien-Dindo grade ≥III complications, and 90-day mortality. Secondary outcomes were blood loss (milliliter), blood transfusion, duration of operation (minute), readmission, reoperation, comprehensive complication index score, bile leak, gastrojejunostomy or duodenojejunostomy leak, postoperative pancreatic fistula, postpancreatectomy hemorrhage, delayed gastric emptying, surgical site infection, intra-abdominal infection, number of harvested lymph nodes, and R0 resection. Pooled odds ratio (OR) or mean difference (MD) of data was calculated using the random-effect model. The grading of recommendations, assessment, development and evaluation approach was used for grading the level of evidence. Results: Four randomized controlled trials yielding 818 patients were included, of which 411 and 407 patients underwent LPD and OPD, respectively. The meta-analysis concluded that 2 approaches were similar, except in the LPD group, the LOS tended to be shorter [MD=-2.54 (-5.17, 0.09), P=0.06], LOS in ICU was shorter [MD=-1 (-1.8, -0.2), P=0.01], duration of operation was longer [MD=75.16 (23.29, 127.03), P=0.005], blood loss was lower [MD=-115.40 (-152.13, -78.68), P<0.00001], blood transfusion was lower [OR=0.66 (0.47, 0.92), P=0.01], and surgical site infection was lower [OR=0.35 (0.12, 0.96), P=0.04]. The overall certainty of the evidence was moderate. Conclusions: Within the hands of highly skilled surgeons in high-volume centers, LPD is feasible and as safe and efficient as OPD.
KW - Whipple
KW - laparoscopy
KW - meta-analysis
KW - minimally invasive surgical procedures
KW - pancreas
KW - pancreatic neoplasms
KW - pancreatoduodenectomy
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U2 - 10.1097/SLA.0000000000005785
DO - 10.1097/SLA.0000000000005785
M3 - Review article
C2 - 36519444
AN - SCOPUS:85152401654
SN - 0003-4932
VL - 277
SP - 742
EP - 755
JO - Annals of surgery
JF - Annals of surgery
IS - 5
ER -