Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected

Mabel L. Rice, Ashley L. Buchanan, George K. Siberry, Kathleen M. Malee, Bret Zeldow, Toni Frederick, Murli U. Purswani, Howard J. Hoffman, Patricia A. Sirois, Renee Smith, Peter Torre, Susannah M. Allison, Paige L. Williams

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: To investigate the risk for language impairment (LI) in children perinatally infected or exposed to HIV. Methods: We evaluated the prevalence of LI in 7-to 16-year-old children with perinatal HIV infection (HIV+) compared with HIV-exposed and uninfected children, using a comprehensive standardized language test (Clinical Evaluation of Language Functioning-Fourth Edition [CELF-4]). LI was classified as primary LI (Pri-LI) (monolingual English exposure and no cognitive or hearing impairment), concurrent LI (Con-LI) (cognitive or hearing impairment), or no LI. Associations of demographic, caregiver, HIV disease, and antiretroviral treatment factors with LI category were evaluated using univariate and multivariable logistic regression models. Results: Of the 468 children with language assessments, 184 (39%) had LI. No difference was observed by HIV infection status for overall LI or for Pri-LI or Con-LI; mean (SD) CELF-4 scores were 88.5 (18.4) for HIV+ versus 87.5 (17.9) for HIV-exposed and uninfected children. After adjustment, black children had higher odds of Pri-LI versus no LI (adjusted odds ratio [aOR] = 2.43, p = .03). Children who were black, Hispanic, had a caregiver with low education or low intelligence quotient, or a nonbiological parent as caregiver had higher odds of Con-LI versus no LI. Among HIV+ children, viral load >400 copies/mL (aOR = 3.04, p < .001), Centers for Disease Control and Prevention Class C (aOR = 2.19, p = .02), and antiretroviral treatment initiation <6 months of age (aOR = 2.12, p = .02) were associated with higher odds of Con-LI versus no LI. Conclusions: Children perinatally exposed to HIV are at high risk for LI, but such risk was not increased for youth with HIV. Risk factors differed for Pri-LI and Con-LI.

Original languageEnglish (US)
Pages (from-to)112-123
Number of pages12
JournalJournal of Developmental and Behavioral Pediatrics
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • antiretroviral therapy
  • language impairment
  • pediatric HIV infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'Language impairment in children perinatally infected with HIV compared to children who were HIV-exposed and uninfected'. Together they form a unique fingerprint.

Cite this