Lamellipodia protrusion: Moving interactions of vinculin and Arp2/3

Susan W. Craig, Hui Chen

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations


A direct, transient interaction between vinculin and Arp2/3 is required to promote receptor-stimulated lamellipodial extension and cell spreading. Vinculin selectively recruits Arp2/3 to the leading edge of the lamellipodium, where it may couple the actin polymerization machinery to adhesion complexes to promote membrane protrusion over ruffling.

Original languageEnglish (US)
Pages (from-to)R236-R238
JournalCurrent Biology
Issue number6
StatePublished - Mar 18 2003

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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