TY - JOUR
T1 - Lactobacillus casei cell wall-induced arthritis in rats
T2 - Cell wall fragment distribution and persistence in chronic arthritis-susceptible LEW/N and -resistant F344/N rats
AU - Lehman, T. J A
AU - Allen, J. B.
AU - Plotz, P. H.
AU - Wilder, R. L.
PY - 1984
Y1 - 1984
N2 - We recently reported that chronic polyarthritis could be induced in LEW/N rats by the injection of group B Lactobacillus casei cell walls in aqueous suspension. To confirm and extend this model we evaluated the pattern of disease in female LEW/N and F344/N rats injected with group B L casei cell wall fragments. Female LEW/N rats developed both acute and chronic polyarthritis following injection, but F344/N rats developed only acute arthritis. To evaluate the role of cell wall deposition and persistence in the pathogenesis of acute and chronic arthritis in these 2 inbred rat strains, group B L casei cell walls internally labeled with 14C L-lysine were prepared and the distribution and persistence of the cell wall fragments measured 1, 3, 20, and 66 days following a single intraperitoneal injection. Labeled group B L casei cell wall fragments were widely distributed and persistent throughout the limbs and tissues of both chronic arthritis-susceptible LEW/N and chronic arthritis-resistant F344/N female rats. The absence of a difference in cell wall distribution between arthritis-susceptible and -resistant inbred rat strains supports the previous hypothesis that inbred LEW/N and F344/N rats differ in their ability to respond to, or neutralize, arthritogenic gram-positive cell wall fragments.
AB - We recently reported that chronic polyarthritis could be induced in LEW/N rats by the injection of group B Lactobacillus casei cell walls in aqueous suspension. To confirm and extend this model we evaluated the pattern of disease in female LEW/N and F344/N rats injected with group B L casei cell wall fragments. Female LEW/N rats developed both acute and chronic polyarthritis following injection, but F344/N rats developed only acute arthritis. To evaluate the role of cell wall deposition and persistence in the pathogenesis of acute and chronic arthritis in these 2 inbred rat strains, group B L casei cell walls internally labeled with 14C L-lysine were prepared and the distribution and persistence of the cell wall fragments measured 1, 3, 20, and 66 days following a single intraperitoneal injection. Labeled group B L casei cell wall fragments were widely distributed and persistent throughout the limbs and tissues of both chronic arthritis-susceptible LEW/N and chronic arthritis-resistant F344/N female rats. The absence of a difference in cell wall distribution between arthritis-susceptible and -resistant inbred rat strains supports the previous hypothesis that inbred LEW/N and F344/N rats differ in their ability to respond to, or neutralize, arthritogenic gram-positive cell wall fragments.
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M3 - Article
C2 - 6431999
AN - SCOPUS:0021636836
SN - 2326-5191
VL - 27
SP - 939
EP - 942
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
IS - 8
ER -