Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004

Thanh Liem Nguyen; Wilina Lim; Huy Anh Bach; Philippe Barboza; Niranjan Bhat; Arnold Bosman; Sofia Boqvist; Rick Brown; Pascale Brudon; Philippe Calain; Maria Cheng; Aaron Curns; Valerie Delpech; Robert Dietz; Cong Doan Nguyen; Rodger Doran; Mirna Du Ry Van Beest Holle; Joel Francart; Keiji Fukuda; Amy Wolkin; Patrice Gautier; Futoshi Hasebe; Peter Horby; Shigeyuki Itamura; Veronique Jestin; Donna Mak; Noel Miranda; Hitoshi Oshitani; Takehiko Saito; Taronna Maines; Reiko Saito; James Mark Simmerman; Terry Tumpey; Timothy Uyeki

doi:10.3201/eid1102.041075

Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004

Thanh Liem Nguyen, Wilina Lim, Huy Anh Bach, Philippe Barboza, Niranjan Bhat, Arnold Bosman, Sofia Boqvist, Rick Brown, Pascale Brudon, Philippe Calain, Maria Cheng, Aaron Curns, Valerie Delpech, Robert Dietz, Cong Doan Nguyen, Rodger Doran, Mirna Du Ry Van Beest Holle, Joel Francart, Keiji Fukuda, Amy WolkinPatrice Gautier, Futoshi Hasebe, Peter Horby, Shigeyuki Itamura, Veronique Jestin, Donna Mak, Noel Miranda, Hitoshi Oshitani, Takehiko Saito, Taronna Maines, Reiko Saito, James Mark Simmerman, Terry Tumpey, Timothy Uyeki

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

To establish whether human-to-human transmission of influenza A H5N1 occurred in the healthcare setting in Vietnam, we conducted a cross-sectional seroprevalence survey among hospital employees exposed to 4 confirmed and 1 probable H5N1 case-patients or their clinical specimens. Eighty-three (95.4%) of 87 eligible employees completed a questionnaire and provided a serum sample, which was tested for antibodies to influenza A H5N1. Ninety-five percent reported exposure to ≥1 H5N1 case-patients; 59 (72.0%) reported symptoms, and 2 (2.4%) fulfilled the definition for a possible H5N1 secondary case-patient. No study participants had detectable antibodies to influenza A H5N1. The data suggest that the H5N1 viruses responsible for human cases in Vietnam in January 2004 are not readily transmitted from person to person. However, influenza viruses are genetically variable, and transmissibility is difficult to predict. Therefore, persons providing care for H5N1 patients should continue to take measures to protect themselves.

Original language	English (US)
Pages (from-to)	210-215
Number of pages	6
Journal	Emerging infectious diseases
Volume	11
Issue number	2
DOIs	https://doi.org/10.3201/eid1102.041075
State	Published - Feb 2005
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Nguyen, T. L., Lim, W., Bach, H. A., Barboza, P., Bhat, N., Bosman, A., Boqvist, S., Brown, R., Brudon, P., Calain, P., Cheng, M., Curns, A., Delpech, V., Dietz, R., Nguyen, C. D., Doran, R., Van Beest Holle, M. D. R., Francart, J., Fukuda, K., ... Uyeki, T. (2005). Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004. Emerging infectious diseases, 11(2), 210-215. https://doi.org/10.3201/eid1102.041075

Nguyen, TL, Lim, W, Bach, HA, Barboza, P, Bhat, N, Bosman, A, Boqvist, S, Brown, R, Brudon, P, Calain, P, Cheng, M, Curns, A, Delpech, V, Dietz, R, Nguyen, CD, Doran, R, Van Beest Holle, MDR, Francart, J, Fukuda, K, Wolkin, A, Gautier, P, Hasebe, F, Horby, P, Itamura, S, Jestin, V, Mak, D, Miranda, N, Oshitani, H, Saito, T, Maines, T, Saito, R, Simmerman, JM, Tumpey, T & Uyeki, T 2005, 'Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004', Emerging infectious diseases, vol. 11, no. 2, pp. 210-215. https://doi.org/10.3201/eid1102.041075

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abstract = "To establish whether human-to-human transmission of influenza A H5N1 occurred in the healthcare setting in Vietnam, we conducted a cross-sectional seroprevalence survey among hospital employees exposed to 4 confirmed and 1 probable H5N1 case-patients or their clinical specimens. Eighty-three (95.4%) of 87 eligible employees completed a questionnaire and provided a serum sample, which was tested for antibodies to influenza A H5N1. Ninety-five percent reported exposure to ≥1 H5N1 case-patients; 59 (72.0%) reported symptoms, and 2 (2.4%) fulfilled the definition for a possible H5N1 secondary case-patient. No study participants had detectable antibodies to influenza A H5N1. The data suggest that the H5N1 viruses responsible for human cases in Vietnam in January 2004 are not readily transmitted from person to person. However, influenza viruses are genetically variable, and transmissibility is difficult to predict. Therefore, persons providing care for H5N1 patients should continue to take measures to protect themselves.",

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AU - Bosman, Arnold

AU - Boqvist, Sofia

AU - Brown, Rick

AU - Brudon, Pascale

AU - Calain, Philippe

AU - Cheng, Maria

AU - Curns, Aaron

AU - Delpech, Valerie

AU - Dietz, Robert

AU - Nguyen, Cong Doan

AU - Doran, Rodger

AU - Van Beest Holle, Mirna Du Ry

AU - Francart, Joel

AU - Fukuda, Keiji

AU - Wolkin, Amy

AU - Gautier, Patrice

AU - Hasebe, Futoshi

AU - Horby, Peter

AU - Itamura, Shigeyuki

AU - Jestin, Veronique

AU - Mak, Donna

AU - Miranda, Noel

AU - Oshitani, Hitoshi

AU - Saito, Takehiko

AU - Maines, Taronna

AU - Saito, Reiko

AU - Simmerman, James Mark

AU - Tumpey, Terry

AU - Uyeki, Timothy

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Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004

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