Lack of gender differences in neuroleptic response in patients with schizophrenia

Debra A. Pinals, Anil K. Malhotra, C. David Missar, David Pickar, Alan Breier

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective: The authors sought to determine if there were gender differences in neuroleptic response in male and female patients with schizophrenia who were matched for clinical and demographic variables and participated in a double-blind trial of traditional antipsychotic drugs. Methods: 24 males (m) and 20 females (f) with schizophrenia or schizoaffective disorder who did not differ in clinical characteristics (age of onset, course of illness, prior hospitalizations, premorbid functioning) participated in an extended drug-free period followed by a neuroleptic trial under double-blind, placebo-controlled conditions. Results: Males and females showed significant improvement in total, positive and negative BPRS symptoms during neuroleptic treatment. However, there were no significant differences in treatment response between sexes. No sex differences were found in baseline drug-free symptomatology, neuroleptic dose or dosage by weight. Conclusions: There were no significant sex differences in neuroleptic treatment response in male and female patients well-matched for clinical, treatment and demographic characteristics. Methodological issues which distinguish this study from prior studies reporting gender differences in neuroleptic response are examined.

Original languageEnglish (US)
Pages (from-to)215-222
Number of pages8
JournalSchizophrenia Research
Issue number3
StatePublished - Dec 15 1996
Externally publishedYes


  • gender
  • neuroleptic treatment
  • schizophrenia
  • sex differences

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • General Psychology


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