Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Margaret B. Rennels; Maria A. Deloria; Michael E. Pichichero; Janet A. Englund; Edwin L. Anderson; Mark C. Steinhoff; Michael D. Decker; Kathryn M. Edwards

doi:10.1016/S0264-410X(02)00171-8

Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Margaret B. Rennels, Maria A. Deloria, Michael E. Pichichero, Janet A. Englund, Edwin L. Anderson, Mark C. Steinhoff, Michael D. Decker, Kathryn M. Edwards

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

Original language	English (US)
Pages (from-to)	S44-S47
Journal	Vaccine
Volume	20
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/S0264-410X(02)00171-8
State	Published - May 31 2002
Externally published	Yes

Keywords

Adsorbed
Aluminum
Vaccines

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/S0264-410X(02)00171-8

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Rennels, M. B., Deloria, M. A., Pichichero, M. E., Englund, J. A., Anderson, E. L., Steinhoff, M. C., Decker, M. D., & Edwards, K. M. (2002). Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions. Vaccine, 20(SUPPL. 3), S44-S47. https://doi.org/10.1016/S0264-410X(02)00171-8

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title = "Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions",

abstract = "The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.",

keywords = "Adsorbed, Aluminum, Vaccines",

author = "Rennels, {Margaret B.} and Deloria, {Maria A.} and Pichichero, {Michael E.} and Englund, {Janet A.} and Anderson, {Edwin L.} and Steinhoff, {Mark C.} and Decker, {Michael D.} and Edwards, {Kathryn M.}",

note = "Funding Information: This work was supported by Contracts NO1-AI15096 (Maryland), NO1-AI05049 (Rochester), NO1-AI02645 (Vanderbilt), NO1-AI05051 (St. Louis), NO1-AI72629 (Baylor), NO1-AI-62515 (Hopkins) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by the vaccine manufacturers Chiron Vaccines, Michigan Department of Public Health, Adventis Pasteur, SmithKline Beecham Biologicals, Speywood Pharmaceuticals (formerly Porton Products), Swiss Serum Vaccine Institute, and Wyeth–Lederle Vaccines. ",

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AU - Rennels, Margaret B.

AU - Deloria, Maria A.

AU - Pichichero, Michael E.

AU - Englund, Janet A.

AU - Anderson, Edwin L.

AU - Steinhoff, Mark C.

AU - Decker, Michael D.

AU - Edwards, Kathryn M.

N1 - Funding Information: This work was supported by Contracts NO1-AI15096 (Maryland), NO1-AI05049 (Rochester), NO1-AI02645 (Vanderbilt), NO1-AI05051 (St. Louis), NO1-AI72629 (Baylor), NO1-AI-62515 (Hopkins) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by the vaccine manufacturers Chiron Vaccines, Michigan Department of Public Health, Adventis Pasteur, SmithKline Beecham Biologicals, Speywood Pharmaceuticals (formerly Porton Products), Swiss Serum Vaccine Institute, and Wyeth–Lederle Vaccines.

PY - 2002/5/31

Y1 - 2002/5/31

N2 - The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

AB - The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

KW - Adsorbed

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Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Abstract

Keywords

ASJC Scopus subject areas

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