L- and M-cone driven large-field and multifocal electroretinograms in sector retinitis pigmentosa

The purpose was to study long-(L-) and middle-wavelength-sensitive (M-) cone-driven ERGs and multifocal ERGs (mfERGs) in sector retinitis pigmentosa (sector RP). Two eyes of two patients with sector RP were measured. ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones or the two simultaneously (both in-phase and in counter-phase) with predefined cone contrast leaving the S-cones unmodulated. For comparison, mfERGs were recorded with the visual evoked response imaging system, using a resolution of 61 hexagonal elements within a 30-degree visual field. The two sector RP patients exhibited a general reduction of the L-/M-cone driven ERG sensitivity. Patient 1 exhibited a slight delay of the M-cone driven ERG. In patient 2, L-cone driven ERG was moderately delayed. In both patients, the phases of the L- and the M-cone driven ERGs were positively correlated with cone contrast. The data of the L/M-cone driven ERGs, the mfERGs and the standard photopic ERGs matched each other qualitatively. We conclude that the sector RP patients were clearly different from normal for both the L- and M-cone driven large-field and the multifocal ERGs. Previously, we investigated L- and M-cone driven ERGs in patients with generalized RP and found several features that differ from the sector RP patients. Our data are in agreement with our previous proposition that amplitudes and phases of the L- and M-cone driven ERGs can be differently affected by retinal disorders.