@article{e71bb645b4cf4ce6912cd8aac671caa3,
title = "Knowledge, attitudes, and planned practice of HIV-positive to HIV-positive transplantation in US transplant centers",
abstract = "Background: HIV+ donor organs can now be transplanted into HIV+ recipients (HIV D+/R+) following the HIV Organ Policy Equity (HOPE) Act. Implementation of the HOPE Act requires transplant center awareness and support of HIV D+/R+ transplants. Methods: To assess center-level barriers to implementation, we surveyed 209 transplant centers on knowledge, attitudes, and planned HIV D+/R+ protocols. Results: Responding centers (n = 114; 56%) represented all UNOS regions. Fifty centers (93 organ programs) planned HIV D+/R+ protocols (kidney n = 48, liver n = 34, pancreas n = 8, heart n = 2, lung = 1), primarily in the eastern United States (28/50). Most (91.2%) were aware that HIV D+/R+ transplantation is legal; 21.4% were unaware of research restrictions. Respondents generally agreed with HOPE research criteria except the required experience with ≥5 HIV+ transplants by organ type. Centers planning HIV D+/R+ protocols had higher transplant volume, HIV+ recipient volume, increased infectious risk donor utilization, and local HIV prevalence (P < 0.01). Centers not planning HIV D+/R+ protocols were more likely to believe their HIV+ candidates would not accept HIV+ donor organs (P < 0.001). Most centers (83.2%) supported HIV+ living donation. Conclusions: Although many programs plan HIV D+/R+ transplantation, center-level barriers remain including geographic clustering of kidney/liver programs and concerns about HIV+ candidate willingness to accept HIV+ donor organs.",
keywords = "HIV, HIV-infected donors, HOPE Act",
author = "{Van Pilsum Rasmussen}, {Sarah E.} and Bowring, {Mary Grace} and Shaffer, {Ashton A.} and Henderson, {Macey L.} and Allan Massie and Tobian, {Aaron A.R.} and Segev, {Dorry L.} and Durand, {Christine M.}",
note = "Funding Information: The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government. This work was supported by the National Institutes of Health grants K23CA177321-01A1 (Durand), R34AI123023 (Durand), U01AI134591 (Durand, Segev), 1R01AI120938-01A1 (Tobian), K24DK101828 (Segev), F30DK116658 (Shaffer), and Johns Hopkins University Center for AIDS Research 1P30AI094189. Funding Information: Funding information This work was supported by the National Institutes of Health grants K23CA177321-01A1 (Durand), R34AI123023 (Durand), U01AI134591 (Durand, Segev), 1R01AI120938-01A1 (Tobian), K24DK101828 (Segev), F30DK116658 (Shaffer), and Johns Hopkins University Center for AIDS Research 1P30AI094189 (Durand). The interpretation and reporting of these data are the responsibility of the author(s) and in no way should be seen as an official policy of or interpretation by the SRTR or the U.S. Government. This work was supported by the National Institutes of Health grants K23CA177321-01A1 (Durand), R34AI123023 (Durand), U01AI134591 (Durand, Segev), 1R01AI120938-01A1 (Tobian), K24DK101828 (Segev), F30DK116658 (Shaffer), and Johns Hopkins University Center for AIDS Research 1P30AI094189. Funding Information: This work was supported by the National Institutes of Health grants K23CA177321-01A1 (Durand), R34AI123023 (Durand), U01AI134591 (Durand, Segev), 1R01AI120938-01A1 (Tobian), K24DK101828 (Segev), F30DK116658 (Shaffer), and Johns Hopkins University Center for AIDS Research 1P30AI094189 (Durand). Publisher Copyright: {\textcopyright} 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = oct,
doi = "10.1111/ctr.13365",
language = "English (US)",
volume = "32",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "10",
}