Knockouts anxious for new therapy

Solomon H. Snyder

doi:10.1038/41656

Knockouts anxious for new therapy

Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Among its many functions, adenosine is a neurotransmitter which acts at the adenosine receptor. By creating knockout mice for one subgroup of adenosine receptors (A_2a), the normal functions of the receptor can be studied. The knockout mice show reduced sensitivity to pain, increased anxiety and similar responses to those shown by wild-type mice to high levels of caffeine. This has led to the conclusion that caffeine normally exerts its responses by blocking the action of the A_2areceptor.

Original language	English (US)
Pages (from-to)	624
Number of pages	1
Journal	Nature
Volume	388
Issue number	6643
DOIs	https://doi.org/10.1038/41656
State	Published - Aug 14 1997

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N2 - Among its many functions, adenosine is a neurotransmitter which acts at the adenosine receptor. By creating knockout mice for one subgroup of adenosine receptors (A2a), the normal functions of the receptor can be studied. The knockout mice show reduced sensitivity to pain, increased anxiety and similar responses to those shown by wild-type mice to high levels of caffeine. This has led to the conclusion that caffeine normally exerts its responses by blocking the action of the A2areceptor.

AB - Among its many functions, adenosine is a neurotransmitter which acts at the adenosine receptor. By creating knockout mice for one subgroup of adenosine receptors (A2a), the normal functions of the receptor can be studied. The knockout mice show reduced sensitivity to pain, increased anxiety and similar responses to those shown by wild-type mice to high levels of caffeine. This has led to the conclusion that caffeine normally exerts its responses by blocking the action of the A2areceptor.

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Knockouts anxious for new therapy

Abstract

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