Abstract
Purpose: To evaluate anti-aging protein klotho levels in the aqueous humor and its association with oxidative stress and inflammation in patients with age-related macular degeneration (AMD). Methods: Levels of klotho, oxidative, and antioxidative stress markers, and proinflammatory and anti-inflammatory markers in the aqueous humor from 28 patients with exudative AMD and 35 age-matched controls were measured. Results: Patients with AMD had lower levels of klotho, which were negatively correlated with macular lesion size. Patients with AMD also exhibited increased levels of 8-hydroxy-2ʹ-deoxyguanosine (8-OHdG) and interleukin (IL)-6 but not tumor necrosis factor‑α, and decreased levels of total antioxidant status (TAS) and IL-10. Moreover, levels of klotho were negatively correlated with levels of 8-OHdG and IL-6, but positively correlated with levels of TSA and IL-10. Conclusion: Klotho levels in the aqueous humor are decreased and associated with oxidative stress and inflammation in patients with exudative AMD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 630-637 |
| Number of pages | 8 |
| Journal | Ocular Immunology and Inflammation |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2022 |
| Externally published | Yes |
Keywords
- Age-related macular degeneration
- inflammation
- klotho
- oxidative stress
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology