Kidney and Urinary Bladder

Jeffrey B. Kopp, Avi Rosenberg, Cory F. Brayton, Jeffrey I. Everitt, Jerrold M. Ward

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter reviews the mouse kidney and lower urinary tract as models for human diseases. Many mouse strains develop spontaneous strain-specific lesions, which can be confused with outcomes or complications of particular experiments. Inspection of pathology slides from a new mouse model may suggest a paucity of glomeruli, or the mouse model may have been developed with the intention of reducing glomerular numbers, to study the effects of glomerular hyperfiltration or chronic kidney disease. Immunologic renal disease is typically associated with the deposition of one or more immunoglobulins, sometimes in association with complement. Transgenic mouse models, and to a lesser extent knockout mouse models, have been developed for a wide range of human glomerular and tubular diseases, although gaps remain with some human disease lacking a phenocopy in mouse. The chapter discusses spontaneous tubular lesions of mice, and genetic disorders of humans and mice.

Original languageEnglish (US)
Title of host publicationPathology of Genetically Engineered and Other Mutant Mice
Number of pages25
ISBN (Electronic)9781119624608
ISBN (Print)9781119624578
StatePublished - Feb 2 2022


  • Genetic disorders
  • Glomerular numbers
  • Human glomerular disease
  • Human tubular diseases
  • Immunologic renal disease
  • Lower urinary tract
  • Mice tubular lesions
  • Mouse kidney

ASJC Scopus subject areas

  • General Veterinary


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