TY - JOUR
T1 - Ketogenic Diets for Adult Neurological Disorders
AU - McDonald, Tanya J.W.
AU - Cervenka, Mackenzie C.
N1 - Publisher Copyright:
© 2018, The American Society for Experimental NeuroTherapeutics, Inc.
PY - 2018/10/14
Y1 - 2018/10/14
N2 - The current review highlights the evidence supporting the use of ketogenic diet therapies in the management of a growing number of neurological disorders in adults. An overview of the scientific literature supporting posited mechanisms of therapeutic efficacy is presented including effects on neurotransmission, oxidative stress, and neuro-inflammation. The clinical evidence supporting ketogenic diet use in the management of adult epilepsy, malignant glioma, Alzheimer’s disease, migraine headache, motor neuron disease, and other neurologic disorders is highlighted and reviewed. Lastly, common adverse effects of ketogenic therapy in adults, including gastrointestinal symptoms, weight loss, and transient dyslipidemia are discussed.
AB - The current review highlights the evidence supporting the use of ketogenic diet therapies in the management of a growing number of neurological disorders in adults. An overview of the scientific literature supporting posited mechanisms of therapeutic efficacy is presented including effects on neurotransmission, oxidative stress, and neuro-inflammation. The clinical evidence supporting ketogenic diet use in the management of adult epilepsy, malignant glioma, Alzheimer’s disease, migraine headache, motor neuron disease, and other neurologic disorders is highlighted and reviewed. Lastly, common adverse effects of ketogenic therapy in adults, including gastrointestinal symptoms, weight loss, and transient dyslipidemia are discussed.
KW - Alzheimer’s disease
KW - Modified Atkins diet
KW - epilepsy
KW - malignant glioma
KW - migraine headache
UR - http://www.scopus.com/inward/record.url?scp=85053675984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053675984&partnerID=8YFLogxK
U2 - 10.1007/s13311-018-0666-8
DO - 10.1007/s13311-018-0666-8
M3 - Article
C2 - 30225789
AN - SCOPUS:85053675984
SN - 1933-7213
VL - 15
SP - 1018
EP - 1031
JO - Neurotherapeutics
JF - Neurotherapeutics
IS - 4
ER -