Ketoconazole does not impair antipyrine clearance in humans

G. T. Blyden, D. R. Abernethy, D. J. Greenblatt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The data are commented and interpreted.

Original languageEnglish (US)
Pages (from-to)225-226
Number of pages2
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Issue number5
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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