The effect of ketoconazole on the kinetics of antipyrine was investigated. The antipyrine Vd showed an overall difference among the 4 trials, but the magnitude of the differences was small. Antipyrine half-life was slightly but not significantly shortened and the antipyrine clearance was essentially identical in the whole study. The data are commented and interpreted.
|Number of pages
|International Journal of Clinical Pharmacology Therapy and Toxicology
|Published - 1986
ASJC Scopus subject areas
- Pharmacology (medical)