Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk

Daniel C. Beachler; Lan L. Gellert; Lisa P. Jacobson; Richard F. Ambinder; Elizabeth C. Breen; Otoniel Martínez-Maza; Charles C. Rabkin; Richard A. Kaslow; Gypsyamber D'Souza

doi:10.1097/QAI.0b013e3181ff976b

Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk

Daniel C. Beachler, Lan L. Gellert, Lisa P. Jacobson, Richard F. Ambinder, Elizabeth C. Breen, Otoniel Martínez-Maza, Charles C. Rabkin, Richard A. Kaslow, Gypsyamber D'Souza

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Kaposi sarcoma-associated herpes virus (KSHV) infects B-cells and is found in non-Hodgkin lymphoma (NHL) B-cell tumors and could therefore contribute to the occurrence of NHL. We performed a nested case-control study including 155 incident NHL cases and matched noncancer controls. Pre-NHL serum was tested for KSHV DNA and antibodies. Serum KSHV DNA was more common in cases than controls (14% versus 6%, P = 0.03), but after adjustment, the difference was not significant. Epstein-Barr virus serum DNA was similarly unassociated with NHL as were KSHV antibodies. KSHV is not a primary cause of NHL in HIV-infected men who have sex with men.

Original language	English (US)
Pages (from-to)	188-192
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	56
Issue number	2
DOIs	https://doi.org/10.1097/QAI.0b013e3181ff976b
State	Published - Feb 1 2011

Keywords

AIDS cancer
DNA
Kaposi sarcoma-associated herpesvirus
MACS
human herpesvirus 8
non-Hodgkin lymphoma

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0b013e3181ff976b

Cite this

Beachler, D. C., Gellert, L. L., Jacobson, L. P., Ambinder, R. F., Breen, E. C., Martínez-Maza, O., Rabkin, C. C., Kaslow, R. A., & D'Souza, G. (2011). Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk. Journal of Acquired Immune Deficiency Syndromes, 56(2), 188-192. https://doi.org/10.1097/QAI.0b013e3181ff976b

Beachler, DC, Gellert, LL, Jacobson, LP , Ambinder, RF, Breen, EC, Martínez-Maza, O, Rabkin, CC, Kaslow, RA & D'Souza, G 2011, 'Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk', Journal of Acquired Immune Deficiency Syndromes, vol. 56, no. 2, pp. 188-192. https://doi.org/10.1097/QAI.0b013e3181ff976b

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abstract = "Kaposi sarcoma-associated herpes virus (KSHV) infects B-cells and is found in non-Hodgkin lymphoma (NHL) B-cell tumors and could therefore contribute to the occurrence of NHL. We performed a nested case-control study including 155 incident NHL cases and matched noncancer controls. Pre-NHL serum was tested for KSHV DNA and antibodies. Serum KSHV DNA was more common in cases than controls (14% versus 6%, P = 0.03), but after adjustment, the difference was not significant. Epstein-Barr virus serum DNA was similarly unassociated with NHL as were KSHV antibodies. KSHV is not a primary cause of NHL in HIV-infected men who have sex with men.",

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AU - Beachler, Daniel C.

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AU - Jacobson, Lisa P.

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AU - Breen, Elizabeth C.

AU - Martínez-Maza, Otoniel

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AB - Kaposi sarcoma-associated herpes virus (KSHV) infects B-cells and is found in non-Hodgkin lymphoma (NHL) B-cell tumors and could therefore contribute to the occurrence of NHL. We performed a nested case-control study including 155 incident NHL cases and matched noncancer controls. Pre-NHL serum was tested for KSHV DNA and antibodies. Serum KSHV DNA was more common in cases than controls (14% versus 6%, P = 0.03), but after adjustment, the difference was not significant. Epstein-Barr virus serum DNA was similarly unassociated with NHL as were KSHV antibodies. KSHV is not a primary cause of NHL in HIV-infected men who have sex with men.

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KW - DNA

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Kaposi sarcoma-associated herpesvirus serum DNA and antibodies not associated with subsequent non-hodgkin lymphoma risk

Abstract

Keywords

ASJC Scopus subject areas

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