Just say no to ATOH: How HIC1 methylation might predispose medulloblastoma to lineage addiction

Kimberly J. Briggs; Charles G. Eberhart; D. Neil Watkins

doi:10.1158/0008-5472.CAN-08-1904

Just say no to ATOH: How HIC1 methylation might predispose medulloblastoma to lineage addiction

Kimberly J. Briggs, Charles G. Eberhart, D. Neil Watkins

School of Medicine

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.

Original language	English (US)
Pages (from-to)	8654-8656
Number of pages	3
Journal	Cancer Research
Volume	68
Issue number	21
DOIs	https://doi.org/10.1158/0008-5472.CAN-08-1904
State	Published - Nov 1 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-08-1904

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abstract = "Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.",

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AU - Briggs, Kimberly J.

AU - Eberhart, Charles G.

AU - Watkins, D. Neil

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N2 - Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.

AB - Hypermethylated in cancer-1 (HIC1) is a tumor suppressor frequently targeted for promoter hypermethylation in medulloblastoma, an embryonal tumor of the cerebellum. Recently, we showed that HIC1 is a direct transcriptional repressor of ATOH1, a proneural transcription factor required for normal cerebellar development, as well as for medulloblastoma cell viability. Because demethylating agents can induce reexpression of silenced tumor suppressors, restoring HIC1 function may present an attractive therapeutic avenue in medulloblastoma by exploiting an apparent addiction to ATOH1.

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Just say no to ATOH: How HIC1 methylation might predispose medulloblastoma to lineage addiction

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