@article{dfe4f703ecb8409496a0650309a565cd,
title = "Joint effect of maternal plasma homocysteine and prepregnancy obesity on child blood pressure: A prospective birth cohort study",
abstract = "Background/Objectives:Elevated homocysteine (Hcy) is a known cardiovascular risk factor. However, its role in intergenerational cardiometabolic risk is unknown. We hypothesized that maternal elevated Hcy can act alone or in combination with maternal prepregnancy obesity to increase child systolic blood pressure (SBP).Methods:This study included 1279 mother-child pairs who were enrolled at birth and followed prospectively up to age 9 years from 2003 to 2014 at the Boston Medical Center.",
author = "H. Wang and Xu, {B. P.} and Xu, {R. B.} and Walker, {S. O.} and G. Wang",
note = "Funding Information: We wish to thank all of the study participants and the Boston Medical Center Labor and Delivery Nursing Staff for their support and help with the study. We thank TR Bartell (Ann & Robert H Lurie Children{\textquoteright}s Hospital of Chicago, Stanley Manne Children{\textquoteright}s Research Institute, Chicago, USA) for English editing. The Boston Birth Cohort (the parent study) was supported in part by the March of Dimes PERI grants (20-FY02-56, #21-FY07-605), and the National Institutes of Health (NIH) grants (R21ES011666, 2R01HD041702, R21HD066471). The follow-up study is supported in part by the NIH grants (U01AI090727, R21AI079872, R01HD086013); and the Maternal and Child Health Bureau (R40MC27443). Dr. Hongjian Wang is supported by a Chinese Scholarships Council scholarship, grants from the National Natural Science Foundation of China (81300156) and PUMC Youth Fund/the Fundamental Research Funds for the Central Universities (3332015103). Publisher Copyright: {\textcopyright} 3/475th percentile.Results:A U-shaped relationship between maternal Hcy and her child SBP was observed.",
year = "2017",
month = sep,
day = "1",
doi = "10.1038/ijo.2017.109",
language = "English (US)",
volume = "41",
pages = "1447--1453",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "9",
}