Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases

Richard T. Johnson; Donald S. Burke; Michael Elwell; Colin J. Leake; Ananda Nisalak; Charles H. Hoke; Wanida Lorsomrudee

doi:10.1002/ana.410180510

Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases

Richard T. Johnson, Donald S. Burke, Michael Elwell, Colin J. Leake, Ananda Nisalak, Charles H. Hoke, Wanida Lorsomrudee

School of Medicine

Research output: Contribution to journal › Article › peer-review

181 Scopus citations

Abstract

The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.

Original language	English (US)
Pages (from-to)	567-573
Number of pages	7
Journal	Annals of neurology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1002/ana.410180510
State	Published - Nov 1985

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases",

abstract = "The distribution of virus and the composition of the mononuclear inflammatory response were studied in the brains of 7 children who died with Japanese encephalitis. Viral antigen was localized to neurons, with greatest involvement in the thalamus and brainstem. Quantitation of perivascular inflammatory responses showed a preponderance of T cells, but only 7 to 30% of these cells were T suppressor/cytotoxic cells. Inflammatory cells invading the parenchyma were predominantly macrophages with small numbers of T cells. B cells remained localized to perivascular cuffs. Viral antigen was progressively cleared in patients with survival of 6 days or more.",

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AU - Leake, Colin J.

AU - Nisalak, Ananda

AU - Hoke, Charles H.

AU - Lorsomrudee, Wanida

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Japanese encephalitis: Immunocytochemical studies of viral antigen and Inflammatory cells in fatal cases

Abstract

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