Ivermectin prophylaxis against experimental Onchocerca volvulus infection in chimpanzees

H. R. Taylor, M. Trpis, E. W. Cupp, B. Brotman, H. S. Newland, P. T. Soboslay, B. M. Greene

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Ivermectin was tested for possible prophylactic action against the third and fourth larval stages (L3 and L4) of Onchocerca volvulus inoculated into chimpanzees. The infective larvae (L3) were obtained from laboratory-raised black flies. Eighteen chimpanzees were inoculated, each with approximately 250 L3. Six were treated with ivermectin (200 μg/kg) on the day of inoculation, 6 were treated with ivermectin on day 28, and 6 were not treated. Monthly skin snips were taken for the next 30 months to detect patent infection. One of the chimpanzees treated with ivermectin on the day of infection developed a patent infection as did 4 of the 6 treated at day 28 and 4 of the 6 control animals. The results suggest that ivermectin may have a partial in vivo effect against the L3 of O. volvulus but has no effect against later larval stages of the parasite.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases


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