Isothiocyanates: Translating the Power of Plants to People

Dushani L. Palliyaguru, Jian Min Yuan, Thomas W. Kensler, Jed W. Fahey

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Isothiocyanates from cruciferous vegetables have been studied extensively in cells and in animals for their disease preventive and therapeutic effects. However, translating their utility to human populations has been both limited and challenging. Herein, clinical trials employing two isothiocyanates, sulforaphane (SFN; 1-isothiocyanato-4-(methylsulfinyl) butane) and phenethyl isothiocyanate (PEITC; 2-isothiocyanatoethylbenzene) that are isolated principally from broccoli and watercress, respectively, are summarized and discussed. Both of these compounds have been used in small human clinical trials, either within food matrices or as single agents, against a variety of diseases ranging from cancer to autism. Results suggest an opportunity to incorporate them, or more likely preparations derived from their source plants, into larger human disease mitigation efforts. The context for the applications of these compounds and plants in evidence-based food and nutritional policy is also evaluated.

Original languageEnglish (US)
Article number1700965
JournalMolecular Nutrition and Food Research
Issue number18
StatePublished - Sep 2018


  • broccoli
  • clinical trials
  • isothiocyanate
  • phenethyl isothiocyanate
  • sulforaphane
  • watercress

ASJC Scopus subject areas

  • Biotechnology
  • Food Science


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