Abstract
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged ,12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandemmass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.
Original language | English (US) |
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Pages (from-to) | 844-847 |
Number of pages | 4 |
Journal | International Journal of Tuberculosis and Lung Disease |
Volume | 20 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1 2016 |
Keywords
- Hair assays
- Isoniazid drug concentrations
- Paediatric TB
- Therapeutic drug monitoring
- Tuberculosis
ASJC Scopus subject areas
- Medicine(all)