Isoniazid hair concentrations in children with tuberculosis: A proof of concept study

V. Mave; A. Chandanwale; A. Kinikar; S. Khadse; A. Kagal; N. NGupte; N. Suryavanshi; S. Nimkar; H. Koli; S. Khwaja; R. Bharadwaj; S. Joshi; H. Horng; L. Z. Benet; G. Ramachandran; K. E. Dooley; A. Gupta; M. Gandhi

doi:10.5588/ijtld.15.0882

Isoniazid hair concentrations in children with tuberculosis: A proof of concept study

V. Mave, A. Chandanwale, A. Kinikar, S. Khadse, A. Kagal, N. NGupte, N. Suryavanshi, S. Nimkar, H. Koli, S. Khwaja, R. Bharadwaj, S. Joshi, H. Horng, L. Z. Benet, G. Ramachandran, K. E. Dooley, A. Gupta, M. Gandhi

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged ,12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandemmass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.

Original language	English (US)
Pages (from-to)	844-847
Number of pages	4
Journal	International Journal of Tuberculosis and Lung Disease
Volume	20
Issue number	6
DOIs	https://doi.org/10.5588/ijtld.15.0882
State	Published - Jun 1 2016

Keywords

Hair assays
Isoniazid drug concentrations
Paediatric TB
Therapeutic drug monitoring
Tuberculosis

ASJC Scopus subject areas

Medicine(all)

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10.5588/ijtld.15.0882

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Mave, V., Chandanwale, A., Kinikar, A., Khadse, S., Kagal, A., NGupte, N., Suryavanshi, N., Nimkar, S., Koli, H., Khwaja, S., Bharadwaj, R., Joshi, S., Horng, H., Benet, L. Z., Ramachandran, G., Dooley, K. E., Gupta, A., & Gandhi, M. (2016). Isoniazid hair concentrations in children with tuberculosis: A proof of concept study. International Journal of Tuberculosis and Lung Disease, 20(6), 844-847. https://doi.org/10.5588/ijtld.15.0882

Mave, V, Chandanwale, A, Kinikar, A, Khadse, S, Kagal, A, NGupte, N, Suryavanshi, N, Nimkar, S, Koli, H, Khwaja, S, Bharadwaj, R, Joshi, S, Horng, H, Benet, LZ, Ramachandran, G, Dooley, KE, Gupta, A & Gandhi, M 2016, 'Isoniazid hair concentrations in children with tuberculosis: A proof of concept study', International Journal of Tuberculosis and Lung Disease, vol. 20, no. 6, pp. 844-847. https://doi.org/10.5588/ijtld.15.0882

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abstract = "Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged ,12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandemmass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.",

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AU - Khadse, S.

AU - Kagal, A.

AU - NGupte, N.

AU - Suryavanshi, N.

AU - Nimkar, S.

AU - Koli, H.

AU - Khwaja, S.

AU - Bharadwaj, R.

AU - Joshi, S.

AU - Horng, H.

AU - Benet, L. Z.

AU - Ramachandran, G.

AU - Dooley, K. E.

AU - Gupta, A.

AU - Gandhi, M.

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Isoniazid hair concentrations in children with tuberculosis: A proof of concept study

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