Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation

Anne R. Gocke, D. Gomika Udugamasooriya, Chase T. Archer, Jiyong Lee, Thomas Kodadek

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Antigen-specific T cells play a major role in mediating the pathogenesis of a variety of autoimmune conditions as well as other diseases. In the context of experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, we present here a general approach to the discovery of highly specific ligands for autoreactive cells. These ligands are obtained from a combinatorial library of hundreds of thousands of synthetic peptoids that is screened simultaneously against two populations of CD4+ T cells. Peptoids that recognize autoreactive T cells with extremely high specificity can be identified in the library. Since no specific knowledge is required regarding the nature of the native antigens recognized by the autoreactive T cells, this technology provides a powerful tool for the enrichment and inhibition of autoimmune cells in a variety of disease states.

Original languageEnglish (US)
Pages (from-to)1133-1139
Number of pages7
JournalChemistry and Biology
Volume16
Issue number11
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • CHEMBIO

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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