Isolated diastolic hypotension and incident heart failure in older adults

Jason L. Guichard, Ravi V. Desai, Mustafa I. Ahmed, Marjan Mujib, Gregg C. Fonarow, Margaret A. Feller, O. James Ekundayo, Vera Bittner, Inmaculada B. Aban, Michel White, Wilbert S. Aronow, Thomas E. Love, George L. Bakris, Susan J. Zieman, Ali Ahmed

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Aging is often associated with increased systolic blood pressure and decreased diastolic blood pressure. Isolated systolic hypertension or an elevated systolic blood pressure without an elevated diastolic blood pressure is a known risk factor for incident heart failure in older adults. In the current study, we examined whether isolated diastolic hypotension, defined as a diastolic blood pressure 12 years of median follow-up, centrally adjudicated incident heart failure developed in 25% and 20% of matched participants with and without isolated diastolic hypotension, respectively (hazard ratio associated with isolated diastolic hypotension: 1.33 [95% CI: 1.10 -1.61]; P=0.004). Among the 5376 prematch individuals, multivariable-adjusted hazard ratio for incident heart failure associated with isolated diastolic hypotension was 1.29 (95% CI: 1.09 -1.53; P=0.003). As in isolated systolic hypertension, among community-dwelling older adults without prevalent heart failure, isolated diastolic hypotension is also a significant independent risk factor for incident heart failure.

Original languageEnglish (US)
Pages (from-to)895-901
Number of pages7
Issue number5
StatePublished - Nov 2011
Externally publishedYes


  • Aging
  • Blood pressure
  • Diastolic
  • Heart failure
  • Pulse pressure

ASJC Scopus subject areas

  • Internal Medicine


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