Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility

K. Datta; P. Rhee; E. Byrnes; G. Garcia-Effron; D. S. Perlin; J. F. Staab; K. A. Marr

doi:10.1128/JCM.01190-13

Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility

K. Datta, P. Rhee, E. Byrnes, G. Garcia-Effron, D. S. Perlin, J. F. Staab, K. A. Marr

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Isavuconazole is an extended-spectrum triazole with in vitro activity against a wide variety of fungal pathogens. Clinical isolates of molds Aspergillus lentulus and Neosartorya udagawae and yeast Cryptococcus gattii VGII (implicated in the outbreak in the Pacific Northwest, North America) exhibit reduced susceptibilities to several azoles but higher susceptibilities to isavuconazole.

Original language	English (US)
Pages (from-to)	3090-3093
Number of pages	4
Journal	Journal of clinical microbiology
Volume	51
Issue number	9
DOIs	https://doi.org/10.1128/JCM.01190-13
State	Published - Sep 2013

ASJC Scopus subject areas

Microbiology (medical)

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abstract = "Isavuconazole is an extended-spectrum triazole with in vitro activity against a wide variety of fungal pathogens. Clinical isolates of molds Aspergillus lentulus and Neosartorya udagawae and yeast Cryptococcus gattii VGII (implicated in the outbreak in the Pacific Northwest, North America) exhibit reduced susceptibilities to several azoles but higher susceptibilities to isavuconazole.",

author = "K. Datta and P. Rhee and E. Byrnes and G. Garcia-Effron and Perlin, {D. S.} and Staab, {J. F.} and Marr, {K. A.}",

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AU - Datta, K.

AU - Rhee, P.

AU - Byrnes, E.

AU - Garcia-Effron, G.

AU - Perlin, D. S.

AU - Staab, J. F.

AU - Marr, K. A.

PY - 2013/9

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AB - Isavuconazole is an extended-spectrum triazole with in vitro activity against a wide variety of fungal pathogens. Clinical isolates of molds Aspergillus lentulus and Neosartorya udagawae and yeast Cryptococcus gattii VGII (implicated in the outbreak in the Pacific Northwest, North America) exhibit reduced susceptibilities to several azoles but higher susceptibilities to isavuconazole.

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Isavuconazole activity against Aspergillus lentulus, Neosartorya udagawae, and Cryptococcus gattii, emerging fungal pathogens with reduced azole susceptibility

Abstract

ASJC Scopus subject areas

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