Is tolerance induction the answer to adolescent non-adherence?

Kiran K. Dhanireddy, Jennifer Maniscalco, Allan D. Kirk

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


By definition, tolerance will eliminate the problem of adolescent medication non-adherence. Although adolescents' propensity toward non-adherence makes them at first glance to be particularly attractive candidates for tolerance trials, there are also immunologic, psychosocial and ethical barriers that temper enthusiasm for their inclusion at present. Limits in emotional and cognitive maturity are combined during the teenage years with adult-like immunologic maturity to lessen the potential for successful implementation of tolerance and near tolerance strategies. Alternatively, an interval step to tolerance in adolescents is to eliminate the medications most likely contributing to non-adherence through harsh side effects such as steroids and calcineurin inhibitors. This manuscript will review the general topic of transplantation tolerance with specific attention given to the application of pro-tolerant therapies in adolescent recipients.

Original languageEnglish (US)
Pages (from-to)357-363
Number of pages7
JournalPediatric transplantation
Issue number3
StatePublished - Jun 2005
Externally publishedYes


  • Adolescent
  • Chimerism
  • Costimulation blockade
  • Lymphocyte depletion
  • Organ transplantation
  • Patient non-adherence
  • Transplantation tolerance

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation


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