Is the failing heart energy starved? On using chemical energy to support cardiac function

Joanne S. Ingwall; Robert G. Weiss

doi:10.1161/01.RES.0000137170.41939.d9

Is the failing heart energy starved? On using chemical energy to support cardiac function

Joanne S. Ingwall, Robert G. Weiss

School of Medicine

Research output: Contribution to journal › Review article › peer-review

452 Scopus citations

Abstract

The requirement of chemical energy in the form of ATP to support systolic and diastolic work of the heart is absolute. Because of its central role in cardiac metabolism and performance, the subject of this review on energetics in the failing heart is ATP. We briefly review the basics of myocardial ATP metabolism and describe how this changes in the failing heart. We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research.

Original language	English (US)
Pages (from-to)	135-145
Number of pages	11
Journal	Circulation research
Volume	95
Issue number	2
DOIs	https://doi.org/10.1161/01.RES.0000137170.41939.d9
State	Published - Jul 23 2004

Keywords

Adenosine triphosphate
Creatine kinase
Familial hypertrophic cardiomyopathy
Heart failure
Phosphocreatine

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/01.RES.0000137170.41939.d9

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abstract = "The requirement of chemical energy in the form of ATP to support systolic and diastolic work of the heart is absolute. Because of its central role in cardiac metabolism and performance, the subject of this review on energetics in the failing heart is ATP. We briefly review the basics of myocardial ATP metabolism and describe how this changes in the failing heart. We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research.",

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AB - The requirement of chemical energy in the form of ATP to support systolic and diastolic work of the heart is absolute. Because of its central role in cardiac metabolism and performance, the subject of this review on energetics in the failing heart is ATP. We briefly review the basics of myocardial ATP metabolism and describe how this changes in the failing heart. We present an analysis of what is now known about the causes and consequences of these energetic changes and conclude by commenting on unsolved problems and opportunities for future basic and clinical research.

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KW - Familial hypertrophic cardiomyopathy

KW - Heart failure

KW - Phosphocreatine

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Is the failing heart energy starved? On using chemical energy to support cardiac function

Abstract

Keywords

ASJC Scopus subject areas

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