Abstract
Cytosolic calcium increases to approximately 3 μM after 15 min of global ischemia. Manipulations that attenuate this increase in cytosolic Ca2+ reduce myocyte death and dysfunction. The increase in cytosolic Ca2+ during ischemia is dependent on an increase in intracellular Na+, suggesting a role for Na/Ca exchange. Typical ischemic values for ionized intra- and extracellular Na+, Ca2+, and membrane potential are consistent with the Na/Ca exchanger operating near equilibrium during ischemia. Studies were undertaken using hearts from mice that overexpress the Na/Ca exchanger to determine if Na/Ca exchanger overexpression enhances or reduces ischemic injury. These studies suggest that overexpression of the Na/Ca exchanger enhances injury in males, but females are protected by a gender-related mechanism.
Original language | English (US) |
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Pages (from-to) | 421-430 |
Number of pages | 10 |
Journal | Annals of the New York Academy of Sciences |
Volume | 976 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Cytosolic calcium
- Ischemia
- Na/Ca exchanger
ASJC Scopus subject areas
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science