@article{553ec54613844cb2aa6dc8478ed337d7,
title = "Is iower IQ in children with epilepsy due to lower parental IQ? A controlled comparison study",
abstract = "AIM The aim of this study was to determine the relationship between parent and child Full-scale IQ (FSIQ) in children with epilepsy and in typically developing comparison children and to examine parent-child IQ differences by epilepsy characteristics. METHOD The study participants were 97 children (50 males, 47 females; age range 8-18y; mean age 12y 3mo, SD 3y1mo) with recent-onset epilepsy including idiopathic generalized (n=43) and idiopathic localization-related epilepsies (n=54); 69 healthy comparison children (38 females, 31 males; age range 8-18y; mean age 12y 8mo, SD 3y 2mo), and one biological parent per child. All participants were administered the Wechsler Abbreviated Scale of Intelligence (WASI). FSIQ was compared in children with epilepsy and typically developing children; FSIQ was compared in the parents of typically developing children and the parents of participants with epilepsy; parent-child FSIQ differences were compared between the groups. RESULTS FSIQ was lower in children with epilepsy than in comparison children (p<0.001). FSIQ of parents of children with epilepsy did not differ from the FSIQ of the parents of typically developing children. Children with epilepsy had significantly lower FSIQ than their parents (p<0.001), whereas comparison children did not. The parent-child IQ difference was significantly higher in the group with epilepsy than the comparison group (p=0.043). Epilepsy characteristics were not related to parent-child IQ difference. INTERPRETATION Parent-child IQ difference appears to be a marker of epilepsy impact independent of familial IQ, epilepsy syndrome, and clinical seizure features. This marker is evident early in the course of idiopathic epilepsies and can be tracked over time.",
author = "Walker, {Natalie M.} and Jackson, {Daren C.} and Kevin Dabbs and Jones, {Jana E.} and Hsu, {David A.} and Stafstrom, {Carl E.} and Sheth, {Raj D.} and Koehn, {Monica A.} and Michael Seidenberg and Hermann, {Bruce P.}",
note = "Funding Information: DAH receives research support from Citizens United for Research on Epilepsy. RDS serves on the editorial board of Epilepsy and Behavior and the Journal of Child Neurology. CES has received compensation as a consultant for Questcor Pharmaceuticals (2011), serves on the Scientific Board of The Charlie Foundation, serves as an Associate Editor of Epilepsia and Co-Editor-in-Chief for Basic Science of Epilepsy Currents, has received royalties from publication of the books Epilepsy and the Ketogenic Diet and Epilepsy: Mechanisms, Models and Translational Perspectives, and received support from the NIH (NINDS RO1 44351 [co-investigator]). BPH serves as an Associate Editor for Epilepsia and receives research support from the NIH (NINDS 2RO1 NS44351 [PI], RO1 AG027161 [co-investigator], P50AG3314 [coinvestigator], 1RO1NS064034 [co-investigator], and RO1AG031790 [co-investigator]). Funding Information: This study was supported by the National Institutes of Health (NINDS ROI 44351), which provided funding for study design, data Funding Information: This study was supported by the National Institutes of Health (NINDS ROI 44351), which provided funding for study design, data collection, and data analysis. The funder was not involved in manuscript preparation or publication decisions. BPH, JEJ, DAH, RDS, MAK, and MS receive research support from the National Institutes of Health (NIH;NINDS RO1 44351 [co-investigators]). This project was supported by the Clinical and Translational Science Award (CTSA) program, previously through the National Center for Research Resources (NCRR) grant 1UL1RR025011, and now by the National Center for Advancing Translational Sciences (NCATS), grant 9U54TR000021. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} The Authors.",
year = "2013",
month = jan,
day = "1",
doi = "10.1111/dmcn.12040",
language = "English (US)",
volume = "55",
pages = "278--282",
journal = "Developmental medicine and child neurology",
issn = "0012-1622",
publisher = "Wiley-Blackwell",
number = "3",
}