TY - JOUR
T1 - Iron and noncontrast magnetic resonance T2∗as a marker of intraplaque iron in human atherosclerosis
AU - Winner, Marshall W.
AU - Sharkey-Toppen, Travis
AU - Zhang, Xiaolan
AU - Pennell, Michael L.
AU - Simonetti, Orlando P.
AU - Zweier, Jay L.
AU - Vaccaro, Patrick S.
AU - Raman, Subha V.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Objective Iron has been implicated in atherogenesis and plaque destabilization, whereas less is known about iron-related proteins in this disease. We compared ex vivo quantities with in vivo vessel wall T2∗, which is a noncontrast magnetic resonance relaxation time that quantitatively shortens with increased tissue iron content. We also tested the hypothesis that patients with carotid atherosclerosis have abnormal T2∗times vs controls that would help support a role for iron in human atherosclerosis. Methods Forty-six patients undergoing carotid endarterectomy and 14 subjects without carotid disease were prospectively enrolled to undergo carotid magnetic resonance imaging. Ex vivo measurements were performed on explanted plaque and 17 mammary artery samples. Results Plaques vs normal arteries had higher levels of ferritin (median, 7.3 [interquartile range (IQR), 4-13.8] vs 1.0 [IQR, 0.6-1.3] ng/mg; P
AB - Objective Iron has been implicated in atherogenesis and plaque destabilization, whereas less is known about iron-related proteins in this disease. We compared ex vivo quantities with in vivo vessel wall T2∗, which is a noncontrast magnetic resonance relaxation time that quantitatively shortens with increased tissue iron content. We also tested the hypothesis that patients with carotid atherosclerosis have abnormal T2∗times vs controls that would help support a role for iron in human atherosclerosis. Methods Forty-six patients undergoing carotid endarterectomy and 14 subjects without carotid disease were prospectively enrolled to undergo carotid magnetic resonance imaging. Ex vivo measurements were performed on explanted plaque and 17 mammary artery samples. Results Plaques vs normal arteries had higher levels of ferritin (median, 7.3 [interquartile range (IQR), 4-13.8] vs 1.0 [IQR, 0.6-1.3] ng/mg; P
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U2 - 10.1016/j.jvs.2014.02.006
DO - 10.1016/j.jvs.2014.02.006
M3 - Article
C2 - 24674272
AN - SCOPUS:84929705419
SN - 0741-5214
VL - 61
SP - 1556
EP - 1564
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 6
ER -