Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Immunopharmacology|
|State||Published - 1980|
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