Iron and deferoxamine in lymphocyte blastogenesis

J. J. Lipsky; P. S. Lietman

Iron and deferoxamine in lymphocyte blastogenesis

J. J. Lipsky, P. S. Lietman

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Murine lymphocytes in tissue culture accumulate ⁵⁹Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

Original language	English (US)
Pages (from-to)	179-187
Number of pages	9
Journal	Journal of Immunopharmacology
Volume	2
Issue number	2
State	Published - 1980

ASJC Scopus subject areas

Immunology
Pharmacology
Toxicology

Cite this

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title = "Iron and deferoxamine in lymphocyte blastogenesis",

abstract = "Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.",

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year = "1980",

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AU - Lipsky, J. J.

AU - Lietman, P. S.

PY - 1980

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N2 - Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

AB - Murine lymphocytes in tissue culture accumulate 59Fe during the blastogenic process. The accumulation of iron is related to the time of maximal activity of DNA synthesis. A chelator of iron, deferoxamine, inhibits blastogenesis with 50% inhibitory concentration of 5 μM. These results suggest that iron is necessary for the blastogenic response and may partially explain the immune deficiency associated with iron deficiency anemia.

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M3 - Article

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JO - Journal of Immunopharmacology

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ER -

Iron and deferoxamine in lymphocyte blastogenesis

Abstract

ASJC Scopus subject areas

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