Iris juvenile xanthogranuloma studied by immunohistochemistry and flow cytometry

Jerry A. Shields, Ralph C. Eagle, Carol L. Shields, Mary Louise Z. Collins, Patrick DePotter

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


An unusual large tan iris mass in a 19-month-old child was removed by iridocyclectomy and studied by light microscopy, immunohistochemistry, and flow cytometry. The excised mass consisted of granulomatous inflammation with numerous osteoclast-like giant cells and scattered atypical Touton giant cells. Immunohistochemistry studies showed that the cells were most consistent with mononuclear histiocytes. Flow cytometry showed that 90% of the cells sampled were T-lymphocytes, with a predominance of T-suppressor cytotoxic cells. Juvenile xanthogranuloma (JXG) of the iris can occur as a large solitary mass, without signs of intraocular inflammation or hyphema.

Original languageEnglish (US)
Pages (from-to)140-144
Number of pages5
JournalOphthalmic Surgery and Lasers
Issue number2
StatePublished - Feb 1 1997

ASJC Scopus subject areas

  • Ophthalmology


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