Ionic iodinated contrast medium and amobarbital sodium mixtures: Potential for precipitation

Lee H. Monsein; Timothy J. Miller; Steven K. Kuwahara; Samuel Sostre; Gerald M. Debrun

doi:10.1148/radiology.184.2.1620833

Ionic iodinated contrast medium and amobarbital sodium mixtures: Potential for precipitation

Lee H. Monsein, Timothy J. Miller, Steven K. Kuwahara, Samuel Sostre, Gerald M. Debrun

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.

Original language	English (US)
Pages (from-to)	385-387
Number of pages	3
Journal	RADIOLOGY
Volume	184
Issue number	2
DOIs	https://doi.org/10.1148/radiology.184.2.1620833
State	Published - Aug 1992

Keywords

Arteriovenous malformations, cerebral, 17.75
Contrast media, complications
Seizures, 134.89

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.184.2.1620833

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abstract = "When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.",

keywords = "Arteriovenous malformations, cerebral, 17.75, Contrast media, complications, Seizures, 134.89",

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AU - Monsein, Lee H.

AU - Miller, Timothy J.

AU - Kuwahara, Steven K.

AU - Sostre, Samuel

AU - Debrun, Gerald M.

PY - 1992/8

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N2 - When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.

AB - When a small amount of diatrizoate meglumine, an ionic iodinated contrast medium, is left in a catheter system before injection of amobarbital sodium or when the contrast medium is intentionally mixed with amobarbital sodium, a potentially dangerous situation occurs. The authors showed in vitro that a dense precipitate forms in this situation. This is due to an acid-base reaction between the relatively acidic contrast medium and basic barbiturate and the subsequent formation of insoluble amobarbital.

KW - Arteriovenous malformations, cerebral, 17.75

KW - Contrast media, complications

KW - Seizures, 134.89

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ER -

Ionic iodinated contrast medium and amobarbital sodium mixtures: Potential for precipitation

Abstract

Keywords

ASJC Scopus subject areas

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