Iodination of arachidonic acid by the iron/H2O2/iodide system

William R. Henderson; Walter C. Hubbard; Seymour J. Klebanoff

doi:10.1007/BF02537238

Iodination of arachidonic acid by the iron/H₂O₂/iodide system

William R. Henderson, Walter C. Hubbard, Seymour J. Klebanoff

School of Medicine

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4 Scopus citations

Abstract

The newly described iron/hydrogen peroxide (H₂O₂)/iodide antimicrobial system iodinates arachidonic acid to form the same products which are generated by peroxidase/H₂O₂/iodide systems. Arachidonic acid is multiply iodinated with the formation of bis-iodohydrins and monoiodinated products which were identified as iodolactones by their high performance liquid chromatography elution patterns and by gas chromatography-mass spectrometric analysis. Iodination of arachidonic acid by the iron/H₂O₂/iodide system appears to proceed via the formation of hydroxyl radicals as an intermediate species. Iodination of unsaturated lipids may contribute to the cytotoxicity of the iron/H₂O₂/iodide system.

Original language	English (US)
Pages (from-to)	390-392
Number of pages	3
Journal	Lipids
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/BF02537238
State	Published - May 1 1983

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Cell Biology

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title = "Iodination of arachidonic acid by the iron/H2O2/iodide system",

abstract = "The newly described iron/hydrogen peroxide (H2O2)/iodide antimicrobial system iodinates arachidonic acid to form the same products which are generated by peroxidase/H2O2/iodide systems. Arachidonic acid is multiply iodinated with the formation of bis-iodohydrins and monoiodinated products which were identified as iodolactones by their high performance liquid chromatography elution patterns and by gas chromatography-mass spectrometric analysis. Iodination of arachidonic acid by the iron/H2O2/iodide system appears to proceed via the formation of hydroxyl radicals as an intermediate species. Iodination of unsaturated lipids may contribute to the cytotoxicity of the iron/H2O2/iodide system.",

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T1 - Iodination of arachidonic acid by the iron/H2O2/iodide system

AU - Henderson, William R.

AU - Hubbard, Walter C.

AU - Klebanoff, Seymour J.

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Y1 - 1983/5/1

N2 - The newly described iron/hydrogen peroxide (H2O2)/iodide antimicrobial system iodinates arachidonic acid to form the same products which are generated by peroxidase/H2O2/iodide systems. Arachidonic acid is multiply iodinated with the formation of bis-iodohydrins and monoiodinated products which were identified as iodolactones by their high performance liquid chromatography elution patterns and by gas chromatography-mass spectrometric analysis. Iodination of arachidonic acid by the iron/H2O2/iodide system appears to proceed via the formation of hydroxyl radicals as an intermediate species. Iodination of unsaturated lipids may contribute to the cytotoxicity of the iron/H2O2/iodide system.

AB - The newly described iron/hydrogen peroxide (H2O2)/iodide antimicrobial system iodinates arachidonic acid to form the same products which are generated by peroxidase/H2O2/iodide systems. Arachidonic acid is multiply iodinated with the formation of bis-iodohydrins and monoiodinated products which were identified as iodolactones by their high performance liquid chromatography elution patterns and by gas chromatography-mass spectrometric analysis. Iodination of arachidonic acid by the iron/H2O2/iodide system appears to proceed via the formation of hydroxyl radicals as an intermediate species. Iodination of unsaturated lipids may contribute to the cytotoxicity of the iron/H2O2/iodide system.

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Iodination of arachidonic acid by the iron/H₂O₂/iodide system

Abstract

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