Iodination of arachidonic acid by the iron/H2O2/iodide system

William R. Henderson, Walter C. Hubbard, Seymour J. Klebanoff

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The newly described iron/hydrogen peroxide (H2O2)/iodide antimicrobial system iodinates arachidonic acid to form the same products which are generated by peroxidase/H2O2/iodide systems. Arachidonic acid is multiply iodinated with the formation of bis-iodohydrins and monoiodinated products which were identified as iodolactones by their high performance liquid chromatography elution patterns and by gas chromatography-mass spectrometric analysis. Iodination of arachidonic acid by the iron/H2O2/iodide system appears to proceed via the formation of hydroxyl radicals as an intermediate species. Iodination of unsaturated lipids may contribute to the cytotoxicity of the iron/H2O2/iodide system.

Original languageEnglish (US)
Pages (from-to)390-392
Number of pages3
Issue number5
StatePublished - May 1 1983

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology


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