Involvement of the CXCL12/CXCR4/CXCR7 Axis in Brain Metastases

Chiara Calatozzolo, Emilio Ciusani, Elena Corsini, Francesco Di Meco, Bianca Pollo, Andrea Salmaggi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The chemokine-receptor axis CXCL12/CXCR4/CXCR7 is involved in a number of pathophysiological processes, among which migration of tumor cells to distant organs and enhancement of angioneogenesis are indeed relevant in the establishment and growth of metastases. Brain metastases are often associated with a poor prognosis, therefore, the identification of mechanisms involved and of possible therapeutic targets are of paramount importance. CXCL12 is largely expressed in the brain microenvironment where it may act as a chemoattractant for tumor cells displaying positivity for either CXCR4 or CXCR7. In a study on 56 patients operated for brain metastasis at a single institution, expression of CXCL12 at the level of endothelial cells in the brain was predictive of shorter survival at univariate analysis. Despite the CXCL12/CXCR4/CXCR7 system not being uniquely involved in metastasization to the brain, it may be a target for brain metastasis prevention/treatment.

Original languageEnglish (US)
Title of host publicationBrain Metastases from Primary Tumors: Epidemiology, Biology, and Therapy
PublisherElsevier Inc.
Number of pages12
ISBN (Print)9780128008966
StatePublished - Apr 2014
Externally publishedYes


  • Brain metastases
  • Cell signaling pathways
  • Chemokine receptor
  • CXCL12
  • CXCR4
  • CXCR7
  • Metastasization

ASJC Scopus subject areas

  • Neuroscience(all)


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