Involvement of PCH family proteins in cytokinesis and actin distribution

John Lippincott, Rong Li

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Pombe Cdc15 homology (PCH) proteins constitute an extensive protein family whose members have been found in diverse eukaryotic organisms. These proteins are characterized by the presence of several conserved sequence and structural motifs. Recent studies in yeast and mammalian cultured cells have implicated these proteins in actin-based processes, in particular, cytokinesis. Here we review the recent findings on the in vivo localization, function, and binding partners of PCH family members. We also provide new microscopy data regarding the in vivo dynamics of a budding yeast PCH protein involved in cytokinesis. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)168-172
Number of pages5
JournalMicroscopy Research and Technique
Issue number2
StatePublished - Apr 15 2000
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology


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