Investigations of membrane protein interactions in cells using fluorescence microscopy

Mahmoud Abouelkheir, Tanaya Roy, Mateusz A. Krzyscik, Ece Özdemir, Kalina Hristova

Research output: Contribution to journalReview articlepeer-review

Abstract

The interactions between proteins in membranes govern many cellular functions. Our ability to probe for such interactions has greatly evolved in recent years due to the introduction of new fluorescence techniques. As a result, we currently have a choice of methods that can be used to assess the spatial distribution of a membrane protein, its association state, and the thermodynamic stability of the oligomers in the native milieu. These biophysical measurements have revealed new insights into important biological processes in cellular membranes.

Original languageEnglish (US)
Article number102816
JournalCurrent Opinion in Structural Biology
Volume86
DOIs
StatePublished - Jun 2024

Keywords

  • Fluorescence
  • Interactions
  • Membrane proteins
  • Receptors

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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