TY - JOUR
T1 - Investigation of human urogenital tract tumors for papovavirus etiology
AU - Shah, K. V.
AU - Daniel, R. W.
AU - Stone, K. R.
AU - Elliott, A. Y.
PY - 1978
Y1 - 1978
N2 - Cells cultured from human urogenital cancer and other cancers as well as cells from noncancerous tissues were examined by immunofluorescent staining with antibodies to T-antigens and capsid antigens of papovaviruses BK viurs (BKV), JC virus, and simian virus 40 (SV40), and to capsid antigens of herpes simplex virus types 1 and 2 and human cytomegalovirus (CMV). Cells from early passage cultures of 123 primary tissues and from 14 continuous lines derived from transitional or renal cell carcinoma were tested. None of the cell preparations was specifically stained with any of the antisera. A serologic comparison of patients with bladder cancer, patients with prostate cancer, and normal control groups for BKV hemagglutination-inhibiting and SV40-neutralizing antibodies showed no differences among the 3 groups. None of the sera in the 3 groups had SV40 or BKV T-antibodies. In tests of supernatants of 35 primary cultures for presence of virus, a single isolation, that of a cytomegalovirus, was made. The study revealed no evidence that infection with papovaviruses of the SV40-polyoma subgroup has any part in the production of bladder and prostate cancer.
AB - Cells cultured from human urogenital cancer and other cancers as well as cells from noncancerous tissues were examined by immunofluorescent staining with antibodies to T-antigens and capsid antigens of papovaviruses BK viurs (BKV), JC virus, and simian virus 40 (SV40), and to capsid antigens of herpes simplex virus types 1 and 2 and human cytomegalovirus (CMV). Cells from early passage cultures of 123 primary tissues and from 14 continuous lines derived from transitional or renal cell carcinoma were tested. None of the cell preparations was specifically stained with any of the antisera. A serologic comparison of patients with bladder cancer, patients with prostate cancer, and normal control groups for BKV hemagglutination-inhibiting and SV40-neutralizing antibodies showed no differences among the 3 groups. None of the sera in the 3 groups had SV40 or BKV T-antibodies. In tests of supernatants of 35 primary cultures for presence of virus, a single isolation, that of a cytomegalovirus, was made. The study revealed no evidence that infection with papovaviruses of the SV40-polyoma subgroup has any part in the production of bladder and prostate cancer.
UR - http://www.scopus.com/inward/record.url?scp=0018191158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018191158&partnerID=8YFLogxK
U2 - 10.1093/jnci/60.3.579
DO - 10.1093/jnci/60.3.579
M3 - Article
C2 - 203710
AN - SCOPUS:0018191158
SN - 0027-8874
VL - 60
SP - 579
EP - 582
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 3
ER -