Investigation of human malignant tumors in india for simian virus 40 etiology

K. V. Shah

doi:10.1093/jnci/42.1.139

Investigation of human malignant tumors in india for simian virus 40 etiology

K. V. Shah

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Sera collected from 975 cancer patients in 10 cities of India were screened for virus-neutralizing and “tumor” (T) antibodies to simian virus 40. All localities of collection were within the known limits of distribution of the rhesus monkey. The overall prevalence of virus-neutralizing antibodies was 5.3%. The protective sera were distributed in all age groups and had low titers of neutralizing antibodies. In analysis of sera from localities where at least one serum was protective, the prevalence of neutralizing antibodies was comparable in all diagnostic categories of cancer except cancer of the urinary bladder, in which 5 of 11 sera were protective. In indirect fluorescent-antibody tests, no T antibodies were demonstrated in any sera, including those from patients with cancer of the bladder.

Original language	English (US)
Pages (from-to)	139-145
Number of pages	7
Journal	Journal of the National Cancer Institute
Volume	42
Issue number	1
DOIs	https://doi.org/10.1093/jnci/42.1.139
State	Published - Jan 1969

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Investigation of human malignant tumors in india for simian virus 40 etiology",

abstract = "Sera collected from 975 cancer patients in 10 cities of India were screened for virus-neutralizing and “tumor” (T) antibodies to simian virus 40. All localities of collection were within the known limits of distribution of the rhesus monkey. The overall prevalence of virus-neutralizing antibodies was 5.3%. The protective sera were distributed in all age groups and had low titers of neutralizing antibodies. In analysis of sera from localities where at least one serum was protective, the prevalence of neutralizing antibodies was comparable in all diagnostic categories of cancer except cancer of the urinary bladder, in which 5 of 11 sera were protective. In indirect fluorescent-antibody tests, no T antibodies were demonstrated in any sera, including those from patients with cancer of the bladder.",

author = "Shah, {K. V.}",

note = "Funding Information: 1 Received August 20, 1968; approved October 25. 1968. 2 Supported by grant E440 from the American Cancer Society, Inc., and grant 5R07-TWOO14I-07CIC from the Public Health Service to The Johns Hopkins Center for Medical Research and Training. I I gratefully acknowledge the generous help of the late Colonel S. L. KaIra. Dr. S. N. Kaul, Dr. Ram Gopal. Dr. Go N. Agarwal, Dr. U. Chaturvedi, Dr. B; Lahiri, Dr. I. M. Gupta, Dr. Saroj Kumari, Dr. D. D. Patel. Dr. J. Roy Chowdhury, Colonel B. L. Taneja, and many others who assisted in various ways in collection of the samples. The excellent technical assistance of David M. Hess, Sarah Willard, and M. G. Sharma is appreciated. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

year = "1969",

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doi = "10.1093/jnci/42.1.139",

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Investigation of human malignant tumors in india for simian virus 40 etiology

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