@article{918a83e5da5e4c6f8fb7a6e6b2e7d88a,
title = "Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses",
abstract = "Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.",
keywords = "Bipolar disorder, Major depression, Personality, Polygenic score, Schizophrenia, Suicidal behavior",
author = "{Consortium on Lithium Genetics (ConLiGen), PsyCourse} and Kalman, {Janos L.} and Tomoya Yoshida and Andlauer, {Till F.M.} and Schulte, {Eva C.} and Kristina Adorjan and Martin Alda and Raffaela Ardau and Aubry, {Jean Michel} and Katharina Brosch and Monika Budde and Caterina Chillotti and Czerski, {Piotr M.} and DePaulo, {Raymond J.} and Andreas Forstner and Goes, {Fernando S.} and Maria Grigoroiu-Serbanescu and Paul Grof and Dominik Grotegerd and Tim Hahn and Maria Heilbronner and Roland Hasler and Urs Heilbronner and Stefanie Heilmann-Heimbach and Pawel Kapelski and Tadafumi Kato and Kohshour, {Mojtaba Oraki} and Susanne Meinert and Tina Meller and Igor Nenadi{\'c} and N{\"o}then, {Markus M.} and Tomas Novak and Nils Opel and Joanna Pawlak and Pfarr, {Julia Katharina} and Potash, {James B.} and Daniela Reich-Erkelenz and Jonathan Repple and H{\'e}l{\`e}ne Richard-Lepouriel and Marcella Rietschel and Ringwald, {Kai G.} and Guy Rouleau and Sabrina Schaupp and Fanny Senner and Giovanni Severino and Alessio Squassina and Frederike Stein and Pavla Stopkova and Fabian Streit and Katharina Thiel and Zandi, {Peter P.}",
note = "Publisher Copyright: {\textcopyright} 2022. The Author(s).",
year = "2022",
month = dec,
day = "1",
doi = "10.1007/s00406-021-01366-5",
language = "English (US)",
volume = "272",
pages = "1611--1620",
journal = "European Archives of Psychiatry and Clinical Neuroscience",
issn = "0940-1334",
publisher = "D. Steinkopff-Verlag",
number = "8",
}