@inproceedings{dd863ad9f8754e76828a24566279652e,
title = "Investigating the effect of cerebral atrophy on brain deformation using subject-specific models",
abstract = "Traumatic brain injuries (TBIs) are a major health risk that increases with age. Natural brain aging results in cerebral atrophy and the enlargement of the ventricular regions. The objective of this study is to investigate the effect of cerebral atrophy on brain biomechanics with subject-specific models to determine the risk of traumatic brain injury (TBI). Utilizing subjects from a longitudinal study of aging in healthy volunteers, we created subject-specific brain models of a small cohort with progressive age-related cerebral atrophy. We then simulate concussive loading conditions to study changes in brain deformation, a correlate to risk of TBI. The results display differing trends with increasing ventricle volume, with some subjects exhibiting increases and others showing decreasing strain. Additional subject simulations are needed to clarify these the causes of these trends.",
keywords = "brain deformation, cerebral atrophy, finite element modeling, Traumatic brain injury, ventricles",
author = "Allen Hong and Aaron Carass and Lianrui Zuo and Prince, \{Jerry L.\} and Ahmed Alshareef",
note = "Funding Information: Research reported in this publication was partially supported by the National Institute of Neurological Disorders and Stroke of the National Institutes of Health under Award Number U01NS112120. The authors also thank all BLSA participants. This research was supported in part by the Intramural Research Program of the NIH, National Institute on Aging. Funding Information: The authors acknowledge NSF REU program: \#1852155 and the Johns Hopkins University Laboratory for Computational Sensing and Robotics (LCSR). Additionally, the authors thank The College of New Jersey School of Engineering for funding travel expenses. Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Medical Imaging 2023: Biomedical Applications in Molecular, Structural, and Functional Imaging ; Conference date: 19-02-2023 Through 22-02-2023",
year = "2023",
doi = "10.1117/12.2654461",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Gimi, \{Barjor S.\} and Andrzej Krol",
booktitle = "Medical Imaging 2023",
}