TY - JOUR
T1 - Invasive pneumococcal disease associated with high case fatality in India
AU - Thomas, Kurien
AU - Mukkai Kesavan, Lalitha
AU - Veeraraghavan, Balaji
AU - Jasmine, Sudha
AU - Jude, John
AU - Shubankar, Mitra
AU - Kulkarni, Poorva
AU - Steinhoff, Mark
N1 - Funding Information:
The authors gratefully acknowledge the financial support provided for the study by the United States Agency for International Development during phase 1 of the project and MSD Pharma during phase 2 of the project with supply of materials and salary for the research officer for the adult component of the study. The diligent work of Ms Rekha Pai, Dr Anand Manoharan, Ms Subhashini, and Ms Aiswarya in the reference laboratory at CMC Vellore has been one of the important reasons for success of this project. The authors acknowledge the secretarial support from Ms Devasena for the project. They also thank the INCLEN Trust and IndiaCLEN office staff at Chennai who have been providing logistic support for the successful completion of the project.
PY - 2013/1
Y1 - 2013/1
N2 - Objective: To study the seroepidemiology and antimicrobial resistance pattern of invasive pneumococcal disease (IPD) in older subjects who are admitted to hospitals in India. Study Design and Setting: Prospective surveillance of IPD in patients older than 18 years in seven large academic teaching hospitals in India from 1993 to 2008. All subjects who had Streptococcus pneumoniae isolated from normally sterile body fluids or were antigen positive in cerebrospinal fluid, ascitic fluid, and pleural fluid were identified as IPD cases in the study. Serotype/group (STG) and minimum inhibitory concentration for penicillin, chloramphenicol, co-trimoxazole (trimethoprim-sulfamethoxazole), erythromycin, and cefotaxime were determined. Results: A total of 1,037 adult subjects with suspected invasive bacterial infection were recruited in the study. S pneumoniae was identified from normally sterile body fluids in 449 (43.3%) subjects. Meningitis (34.3%) and pneumonia (33.9%) were the most common clinical conditions associated with IPD. The case fatality was 25-30% across all age groups. Penicillin resistance was low at 2.7% overall. Resistance to co-trimoxazole was noted to be high and increasing in the study period from 42.9% in 1993 to 85.2% in 2008 (P = 0.001). The most common STG was serotype 1, which accounted for 22.9% of all isolates. The 23-valent pneumococcal polysaccharide vaccine covered 83.3% of the STGs (49/54; 95% confidence interval: 79.7, 96.9) for patients older than 60 years. Conclusion: IPD continues to be a problem in India and is associated with high case fatality in spite of treatment in the hospital setting. Penicillin resistance is currently low in India. More than 80% of invasive STGs causing disease in the elderly in India are included in the formulation of polysaccharide pneumococcal vaccine.
AB - Objective: To study the seroepidemiology and antimicrobial resistance pattern of invasive pneumococcal disease (IPD) in older subjects who are admitted to hospitals in India. Study Design and Setting: Prospective surveillance of IPD in patients older than 18 years in seven large academic teaching hospitals in India from 1993 to 2008. All subjects who had Streptococcus pneumoniae isolated from normally sterile body fluids or were antigen positive in cerebrospinal fluid, ascitic fluid, and pleural fluid were identified as IPD cases in the study. Serotype/group (STG) and minimum inhibitory concentration for penicillin, chloramphenicol, co-trimoxazole (trimethoprim-sulfamethoxazole), erythromycin, and cefotaxime were determined. Results: A total of 1,037 adult subjects with suspected invasive bacterial infection were recruited in the study. S pneumoniae was identified from normally sterile body fluids in 449 (43.3%) subjects. Meningitis (34.3%) and pneumonia (33.9%) were the most common clinical conditions associated with IPD. The case fatality was 25-30% across all age groups. Penicillin resistance was low at 2.7% overall. Resistance to co-trimoxazole was noted to be high and increasing in the study period from 42.9% in 1993 to 85.2% in 2008 (P = 0.001). The most common STG was serotype 1, which accounted for 22.9% of all isolates. The 23-valent pneumococcal polysaccharide vaccine covered 83.3% of the STGs (49/54; 95% confidence interval: 79.7, 96.9) for patients older than 60 years. Conclusion: IPD continues to be a problem in India and is associated with high case fatality in spite of treatment in the hospital setting. Penicillin resistance is currently low in India. More than 80% of invasive STGs causing disease in the elderly in India are included in the formulation of polysaccharide pneumococcal vaccine.
KW - 23-valent pneumococcal polysaccharide vaccine
KW - Antimicrobial resistance
KW - Invasive pneumococcal disease
KW - PPV23
KW - S pneumoniae
KW - STG
KW - Serotype group
KW - Surveillance
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U2 - 10.1016/j.jclinepi.2012.04.006
DO - 10.1016/j.jclinepi.2012.04.006
M3 - Article
C2 - 23177893
AN - SCOPUS:84870001734
SN - 0895-4356
VL - 66
SP - 36
EP - 43
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 1
ER -