Intrinsic and synaptic plasticity in the vestibular system

Aryn H. Gittis, Sascha du Lac

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of motor learning calibrate the circuit throughout life. Learning in the vestibulo-ocular reflex depends initially on the activity of Purkinje cells in the cerebellar flocculus, but consolidated memories appear to be stored downstream of Purkinje cells, probably in the vestibular nuclei. Recent studies have demonstrated that the neurons of the vestibular nucleus possess the capacity for both synaptic and intrinsic plasticity. Mechanistic analyses of a novel form of firing rate potentiation in neurons of the vestibular nucleus have revealed new rules of plasticity that could apply to spontaneously firing neurons in other parts of the brain.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalCurrent Opinion in Neurobiology
Issue number4
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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