Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas

Thomas C. Kwee, Craig J. Galbán, Christina Tsien, Larry Junck, Pia C. Sundgren, Marko K. Ivancevic, Timothy D. Johnson, Charles R. Meyer, Alnawaz Rehemtulla, Brian D. Ross, Thomas L. Chenevert

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


This study aimed to determine the potential value of intravoxel water diffusion heterogeneity imaging for brain tumor characterization and evaluation of high-grade gliomas, by comparing an established heterogeneity index (α value) measured in human high-grade gliomas to those of normal appearing white and grey matter landmarks. Twenty patients with high-grade gliomas prospectively underwent diffusion-weighted magnetic resonance imaging using multiple b-values. The stretched-exponential model was used to generate α and distributed diffusion coefficient (DDC) maps. The α values and DDCs of the tumor and contralateral anatomic landmarks were measured in each patient. Differences between α values of tumors and landmark tissues were assessed using paired t-tests. Correlation between tumor α and tumor DDC was assessed using Pearson's correlation coefficient. Mean α of tumors was significantly lower than that of contralateral frontal white matter (p = 0.0249), basal ganglia (p < 0.0001), cortical grey matter (p < 0.0001), and centrum semiovale (p = 0.0497). Correlation between tumor α and tumor DDC was strongly negative (Pearson correlation coefficient, -0.8493; p < 0.0001). The heterogeneity index α of human high-grade gliomas is significantly different from those of normal brain structures, which potentially offers a new method for evaluating brain tumors. The observed negative correlation between tumor α and tumor DDC requires further investigation.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalNMR in biomedicine
Issue number2
StatePublished - Feb 2010
Externally publishedYes


  • Brain tumor
  • Diffusion-weighted magnetic resonance imaging
  • Glioma
  • Intravoxel water diffusion heterogeneity
  • Stretched-exponential

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy


Dive into the research topics of 'Intravoxel water diffusion heterogeneity imaging of human high-grade gliomas'. Together they form a unique fingerprint.

Cite this