Abstract
To avoid the side effects of systemic administration of ganciclovir (GCV) for the treatment of cytomegalovirus (CMV) retinitis, we studied transscleral iontophoresis of GCV into rabbit eyes. After a single application with 20% (w/w) aqueous solution of GCV at 1.0 mA for 15 min gave a vitreal/retinal level of GCV at 74±17 ug/ml at 2 hours as determined by HPLC. At 24 hours after iontophoresis the vitreal/retinal level was above therapeutic level at 4.2±0.6 ug/ml. At 72 hours, there was still detectable level in the vitreous/retina. Hence, transscleral iontophoresis is able to deliver effective dose of GCV into the vitreous. Multiple applications of iontophoresis should be examined as a possible means of CMV treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 571-575 |
| Number of pages | 5 |
| Journal | Journal of Ocular Pharmacology |
| Volume | 10 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Ophthalmology
- Pharmacology
- Pharmacology (medical)
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