Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma: Autopsy findings

Lina S Correa Cerro; Fausto J Rodriguez; Erika Rodriguez

Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma: Autopsy findings

Lina S Correa Cerro, Fausto J Rodriguez, Erika Rodriguez

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Lung cancer is the most common cause of cancer-related death in the United States. Adenocarcinoma is the most common primary malignancy of the lung. Approximately 50-80% of pulmonary adenocarcinomas have a known oncogenic driver mutation, KRAS mutation being the most common. In the current study, we report the autopsy findings of two patients with advanced stage lung adenocarcinoma presenting with massive intravascular dissemination. Both cases showed a predominantly solid pattern as well as a KRAS mutation. The clinicopathologic implications are discussed.

Original language	English (US)
Pages (from-to)	8456-8463
Number of pages	8
Journal	International Journal of Clinical and Experimental Pathology
Volume	9
Issue number	8
State	Published - 2016

Keywords

Adenocarcinoma
Brain metastasis
Disseminated intravascular tumor
KRAS mutation
Non-small cell lung cancer
Pulmonary tumor microembolism

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

Cite this

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title = "Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma: Autopsy findings",

abstract = "Lung cancer is the most common cause of cancer-related death in the United States. Adenocarcinoma is the most common primary malignancy of the lung. Approximately 50-80% of pulmonary adenocarcinomas have a known oncogenic driver mutation, KRAS mutation being the most common. In the current study, we report the autopsy findings of two patients with advanced stage lung adenocarcinoma presenting with massive intravascular dissemination. Both cases showed a predominantly solid pattern as well as a KRAS mutation. The clinicopathologic implications are discussed.",

keywords = "Adenocarcinoma, Brain metastasis, Disseminated intravascular tumor, KRAS mutation, Non-small cell lung cancer, Pulmonary tumor microembolism",

author = "Cerro, {Lina S Correa} and Rodriguez, {Fausto J} and Erika Rodriguez",

year = "2016",

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T1 - Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma

T2 - Autopsy findings

AU - Cerro, Lina S Correa

AU - Rodriguez, Fausto J

AU - Rodriguez, Erika

PY - 2016

Y1 - 2016

N2 - Lung cancer is the most common cause of cancer-related death in the United States. Adenocarcinoma is the most common primary malignancy of the lung. Approximately 50-80% of pulmonary adenocarcinomas have a known oncogenic driver mutation, KRAS mutation being the most common. In the current study, we report the autopsy findings of two patients with advanced stage lung adenocarcinoma presenting with massive intravascular dissemination. Both cases showed a predominantly solid pattern as well as a KRAS mutation. The clinicopathologic implications are discussed.

AB - Lung cancer is the most common cause of cancer-related death in the United States. Adenocarcinoma is the most common primary malignancy of the lung. Approximately 50-80% of pulmonary adenocarcinomas have a known oncogenic driver mutation, KRAS mutation being the most common. In the current study, we report the autopsy findings of two patients with advanced stage lung adenocarcinoma presenting with massive intravascular dissemination. Both cases showed a predominantly solid pattern as well as a KRAS mutation. The clinicopathologic implications are discussed.

KW - Adenocarcinoma

KW - Brain metastasis

KW - Disseminated intravascular tumor

KW - KRAS mutation

KW - Non-small cell lung cancer

KW - Pulmonary tumor microembolism

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JF - International Journal of Clinical and Experimental Pathology

IS - 8

ER -

Intravascular malignant cell dissemination pattern in KRAS mutant advanced lung adenocarcinoma: Autopsy findings

Abstract

Keywords

ASJC Scopus subject areas

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