Intrauterine progesterone treatment of early endometrial cancer

Fredrick J. Montz, Robert E. Bristow, Alessandro Bovicelli, Rafael Tomacruz, Robert J. Kurman

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


OBJECTIVE: Our purpose was to assess the feasibility of using a progesterone-containing intrauterine device (IUD) to treat presumed Federation Internationale Gynecologie et d'Obstetrique (FIGO) stage IA, grade 1 endometrioid cancer in women at high risk for perioperative complications. STUDY DESIGN: Candidates were women with American Society of Anesthesiologists class III or IV grade 1 endometrioid cancer and no imaging evidence of myometrial invasion. Subjects underwent hysteroscopy, curettage, and IUD placement, followed by endometrial biopsy every 3 months for 1 year. The records of similar patients treated surgically during the 3 years before protocol initiation were reviewed for comparison. RESULTS: Sixteen patients fulfilled study criteria. Fourteen consented to participation; one was excluded at the time of IUD placement (grade 2 disease identified) and one was lost to follow-up. Twelve subjects have been followed up to 36 months; results of biopsies were negative in 7 of 11 at 6 months and 6 of 8 at 12 months. No IUD-related complications, except for expulsion, occurred. Sixteen complications (one fatal) occurred in 9 of the 15 control patients. CONCLUSION: Intrauterine progesterone appears to eradicate some cases of presumed stage IA, grade 1 endometrioid cancer in women at high risk for perioperative morbidity.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - Jan 1 2002


  • Endometrial cancer
  • Hormonal treatment
  • Progesterone-containing intrauterine device

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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