Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

Raya S. Brown; Mark S. Kaminski; Susan J. Fisher; Alfred E. Chang; Richard L. Wahl

doi:10.1016/S0969-8051(97)00099-1

Intratumoral microdistribution of [¹³¹I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

Raya S. Brown, Mark S. Kaminski, Susan J. Fisher, Alfred E. Chang, Richard L. Wahl

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [¹³¹I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.

Original language	English (US)
Pages (from-to)	657-663
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/S0969-8051(97)00099-1
State	Published - Oct 1997
Externally published	Yes

Keywords

Autoradiography
Human
Lymphoma
Monoclonal antibodies
Pan-B cell
Radioimmunotherapy

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(97)00099-1

Cite this

@article{2e75415ee5494bf1919e2df30e719563,

title = "Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy",

abstract = "Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.",

keywords = "Autoradiography, Human, Lymphoma, Monoclonal antibodies, Pan-B cell, Radioimmunotherapy",

author = "Brown, {Raya S.} and Kaminski, {Mark S.} and Fisher, {Susan J.} and Chang, {Alfred E.} and Wahl, {Richard L.}",

note = "Funding Information: We thank Jeanette Roesner and Gayle A. Jackson for their &u&z technical assistance and Will Jaynes for the help in the image analysis. This work was supported by the National Cancer Institute and National Institutes of Health grunts PO1 -CA-42768, ROl-CA-42768 and MO1 -RR-00042.",

year = "1997",

month = oct,

doi = "10.1016/S0969-8051(97)00099-1",

language = "English (US)",

volume = "24",

pages = "657--663",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

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T1 - Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

AU - Brown, Raya S.

AU - Kaminski, Mark S.

AU - Fisher, Susan J.

AU - Chang, Alfred E.

AU - Wahl, Richard L.

N1 - Funding Information: We thank Jeanette Roesner and Gayle A. Jackson for their &u&z technical assistance and Will Jaynes for the help in the image analysis. This work was supported by the National Cancer Institute and National Institutes of Health grunts PO1 -CA-42768, ROl-CA-42768 and MO1 -RR-00042.

PY - 1997/10

Y1 - 1997/10

N2 - Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.

AB - Intratumoral microdistribution of radiolabeled anti-CD37 murine monoclonal antibody, [131I]MB-1, in lymph nodes from five patients with non-Hodgkin's B-cell lymphoma following radioimmunotherapy were evaluated by microautoradiography and image analysis of macroautoradiographs. Microdistribution of radioactivity was highly heterogeneous: silver grain counts varied from 28-70 to 8-10 per 400X field, and the coefficients of variations calculated by image analysis ranged between 42.5 and 79.3%. Variable radiation doses delivered could have contributed to the limited durability of tumor regression.

KW - Autoradiography

KW - Human

KW - Lymphoma

KW - Monoclonal antibodies

KW - Pan-B cell

KW - Radioimmunotherapy

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