Intratumoral hypoxia, radiation resistance, and HIF-1

Research output: Contribution to journalReview articlepeer-review

169 Scopus citations


Failure to achieve complete remission after radiation therapy is a predictor of patient mortality, and hypoxic cancer cells are more likely to survive radiation therapy. Recent studies have shown that radiation-induced endothelial cell death results in secondary tumor cell killing. In this issue of Cancer Cell, Moeller et al. (2004) now provide evidence that radiation induces HIF-1-mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival.

Original languageEnglish (US)
Pages (from-to)405-406
Number of pages2
JournalCancer cell
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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