TY - JOUR
T1 - Intraocular tuberculosis
AU - Cutrufello, Nicholas J.
AU - Karakousis, Petros C.
AU - Fishler, Jane
AU - Albini, Thomas A.
N1 - Funding Information:
Supported by an unrestricted grant from Research to Prevent Blindness, New York, NY.
PY - 2010/8
Y1 - 2010/8
N2 - Intraocular manifestations of tuberculosis (TB) are rare, but TB infection is common worldwide, especially in developing economies, and in immigrant populations and immunocompromised patients in developed nations. The current review focuses on the clinical characteristics and diagnostic modalities useful in the diagnosis of intraocular TB. Specifically, IFN-γ Release Assays (IGRAs), antigen-detection assays, and polymerase chain reactions will be discussed. Clinical management of TB patients includes counseling and testing for HIV infection. The use of corticosteroids along with anti-tuberculous medications and special therapeutic considerations in immunocompromised patients are discussed.
AB - Intraocular manifestations of tuberculosis (TB) are rare, but TB infection is common worldwide, especially in developing economies, and in immigrant populations and immunocompromised patients in developed nations. The current review focuses on the clinical characteristics and diagnostic modalities useful in the diagnosis of intraocular TB. Specifically, IFN-γ Release Assays (IGRAs), antigen-detection assays, and polymerase chain reactions will be discussed. Clinical management of TB patients includes counseling and testing for HIV infection. The use of corticosteroids along with anti-tuberculous medications and special therapeutic considerations in immunocompromised patients are discussed.
KW - HIV
KW - IFN-γ release assays (IGRA)
KW - Lipoarabinomannan (LAM)
KW - Ocular tuberculosis' PCR
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U2 - 10.3109/09273948.2010.489729
DO - 10.3109/09273948.2010.489729
M3 - Review article
C2 - 20662660
AN - SCOPUS:77954882238
SN - 0927-3948
VL - 18
SP - 281
EP - 291
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 4
ER -