Intramembrane proteolysis controls diverse signalling pathways throughout evolution

Sinisa Urban; Matthew Freeman

doi:10.1016/S0959-437X(02)00334-9

Intramembrane proteolysis controls diverse signalling pathways throughout evolution

Sinisa Urban, Matthew Freeman

Research output: Contribution to journal › Review article › peer-review

128 Scopus citations

Abstract

Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

Original language	English (US)
Pages (from-to)	512-518
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/S0959-437X(02)00334-9
State	Published - Oct 1 2002
Externally published	Yes

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/S0959-437X(02)00334-9

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abstract = "Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.",

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AB - Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

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M3 - Review article

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AN - SCOPUS:0036777494

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Intramembrane proteolysis controls diverse signalling pathways throughout evolution

Abstract

ASJC Scopus subject areas

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