Intramembrane proteolysis controls diverse signalling pathways throughout evolution

Sinisa Urban, Matthew Freeman

Research output: Contribution to journalReview articlepeer-review

128 Scopus citations


Regulated intramembrane proteolysis (RIP) has recently emerged as a conserved mechanism for controlling many signalling pathways in both prokaryotes and eukaryotes. Although early examples were confined to the activation of membrane-tethered transcription factors in the cell receiving the signal, recent analysis indicates that RIP also regulates the emission of factors involved in intercellular communication.

Original languageEnglish (US)
Pages (from-to)512-518
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number5
StatePublished - Oct 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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